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Filtering by: Alternative title ssim Structure and proposed mechanism of α-glycerophosphate oxidase from Mycoplasma pneumoniae Remove constraint Alternative title ssim: Structure and proposed mechanism of α-glycerophosphate oxidase from Mycoplasma pneumoniae Degree Level Doctoral Remove constraint Degree Level: Doctoral Subject Peroxidase -- Structure-activity relationships Remove constraint Subject: Peroxidase -- Structure-activity relationships

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  • Biophysical analyses of peroxiredoxins and a partner reductase

    Creator:
    Hall, Andrea Renée
    Abstract:
    Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
    Resource Type:
    Dissertation
    Full Text:
    characterization of select Prxs and a Prx reductase to elucidate their structure-function relationships. It

  • Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

    Creator:
    Perkins, Arden
    Abstract:
    Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
    Resource Type:
    Dissertation
    Full Text:
    ) assess the impact of modifications on structure and dynamics (Chapter 4) and define the roles of highly