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Filtering by: Subject Time-of-flight mass spectrometry Degree Level Doctoral Subject Proteomics

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:

Huang, Lin

Abstract:

Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...

Resource Type:

Dissertation

Full Text:

memory. Firstly, we explored the applicability of travelling wave ion mobility mass spectrometry
Mass-spectrometric Methods for Quantitative Proteomics and Post-translational Modification Mapping

Creator:

Motorykin, Ievgen

Abstract:

Signal transduction within and between cells is at the core of biological activity in all living systems. Signaling networks are required for regulating biological functions, including growth, development and survival. Deregulation of signaling cascades has been linked to chronic and acute diseases and disorders This thesis focuses on mass spectrometry...

Resource Type:

Dissertation
Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:

Wu, Jianyong

Abstract:

The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...

Resource Type:

Dissertation

Full Text:

, Brian Arbogast, Jeff Morre and the rest of the mass spectrometry group for their support. Thanks are