There has been no toxicologic proof that the long-term, low-level
exposure of man to chlorophenothane (DDT) is linked with an
increased susceptibility to toxicity or disease. Acute pretreatment
of rats with 75-100 mg/kg DDT has been demonstrated to potentiate
CCI₄-induced hepatotoxicity in that species (McLean and McLean,
1966). Since the...
Virtually nothing is known regarding the quantitative significance
of the several catabolic sequences involved in the breakdown of
glucose in the intact rat. Studies in this and other laboratories have
shown that the Embden-Meyerhof-Parnas pathway, the pentose
phosphate pathway and the glucuronic acid pathway are operative in
several tissues of...
Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...