DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
This dissertation consists of three essays that provide comprehensive insights into the complex dynamics shaping entrepreneurial and organizational outcomes. In the first essay I incorporate the Biophilia Hypothesis and the Challenge Hindrance Stressor framework to study entrepreneurial creativity. The findings emphasize the importance of more frequent nature visits for entrepreneurs...
An open area of research in complex systems is to move reliability and failure assessments earlier in the engineering design process. When compared to later design, early decisions are cost effective and have a large impact on the system. Standard methods are limited by the availability of data and often...
Biological organisms, phenomena and strategies, herein referred to as biological systems, provide a rich set of analogies that can be used to inspire engineering innovation. Biologically-inspired, or biomimetic, designs are publicly viewed as creative and novel solutions to human problems. Moreover, some biomimetic designs have become so commonplace that it...
A rapid nuclear isolation technique was adapted in
order to examine the question of DNA precursor
compartmentation in mammalian cells. By using this method
a reproducible proportion of the cellular nucleotides
remained associated with the isolated nuclei.
Examination, at several different cell densities, of
exponentially growing HeLa cells showed that...
Dearomatization reactions exist broadly in biosynthesis and chemical synthesis. The highly functionalized atoms of arenes can be masked by it aromaticity, and upon dearomatization, those reactive atoms can be readily applied to bond formation and further manipulation. The total synthesis of (–)-cephalotaxine and (–)- homoharringtonine is described via an oxidative...
A number of Antarctic marine psychrophilic bacteria were
isolated having the ability to grow and accumulate ¹⁴ C-TMG only at
temperatures below 20 C. It was shown that galactose rather than
lactose was the primary inducer and utilizable substrate for the
permease system. Further studies with a Vibrio species (Ant-12),...