Index Catalog // ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: either phase I or phase II enzymes could have an effect on the efficacy or toxicity of therapeutic drugs

Chlordecone impaired biliary excretion : in vivo and in vitro correlates

Creator:: Rochelle, Lori G.
Resource Type:: Dissertation
Full Text:: Corvallis, Oregon 97331-3803 12 Abstract The effect of in vitro chlordecone (CD) treatment on hepatic

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Creator:: Park, Yeong-Chul
Resource Type:: Dissertation
Full Text:: selenite on its absorption 25 Time course of sodium selenite transport 26 Chemical forms in the vascular

Oxidative stress and carcinogenesis in trout

Creator:: Kelly, Jack D.
Resource Type:: Dissertation
Full Text:: approved:4 David E. Williams The inhibitory effect of antioxidants in the multi-stage chemical

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: synthesis and lipid metabolism (Cyr et al., 1988) but no evidence of a direct effect on Vg synthesis is

Congener-specific disposition of polychlorinated biphenyls in rainbow trout

Creator:: Foster, Eugene P.
Resource Type:: Dissertation
Full Text:: fish (Zabel et al., 1995). Interactions of compounds with minimal effect on metabolizing enzyme

Sex and life stage sensitivity of rainbow trout to xenoestrogens

Creator:: Carlson, David B., 1970-
Abstract:: Numerous natural and anthropogenic chemicals interact with endocrine systems of animals. The most widely studied of these endocrine active chemicals (EACs) are estrogen receptor agonists and antagonists. Because of the many important roles of estrogens in animals, xenoestrogens have the potential to impact environmental health. It has been proposed that...
Resource Type:: Dissertation
Full Text:: exposure to aryl hydrocarbon receptor (AbR) agonists based on the sum of chemical affinity for AhR

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: 3-2 Effect of AHR genotype on mortality of offspring born to DBP-treated dams

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation
Full Text:: methylation in different biological human tissues. Particularly, the effect of arsenic exposure on

Alterations in mink reproductive physiology following exposure to coplanar and noncoplanar polychlorinated biphenyls (PCBs)

Creator:: Patnode, Kathleen A., 1959-
Abstract:: Female mink (Mustela vison) are highly sensitive to polychlorinated biphenyl (PCB)-induced reproductive impairment. The goal of this research was to develop a better understanding of the mechanism of PCB-induced effects on female mink, mink embryos, and surviving mink kits. Anestrous, juvenile female mink and pregnant, adult mink were exposed to...
Resource Type:: Dissertation
Full Text:: Kathleen A. Patnode for the degree of Doctor of Philosophy in Toxicology presented on May 4, 1995. Title

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on December 9. 2005. Title: Assessing Mechanisms

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Creator:: Warner, Kara E.
Abstract:: Natural and synthetic estrogenic compounds detected in surface waters have been linked to endocrine signaling disruption in several species. Endogenous estrogen contributes to cartilage and bone deposition during development in vertebrates, and is susceptible to perturbation from xenoestrogens. The goals of this work were to develop a teleost model to...
Resource Type:: Dissertation

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: responsible for most of the sediment sample preparation for chemical analysis for Chapter 3. Dr. Robert

Environmental Mixtures and Selected Health Outcomes in the US Population

Creator:: Przybyla, Jennifer
Abstract:: The human health effects of exposure to numerous single environmental contaminants have been well characterized. Yet, biomonitoring studies have detected multiple environmental chemicals in humans, highlighting the need to investigate the health effects of exposure to multiple environmental chemicals. Environmental data is highly complex, therefore current methods of defining environmental...
Resource Type:: Dissertation
Full Text:: ......................................................................... 8 Evaluation of chemical mixtures on human health

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Creator:: Fisher, Joseph A.
Abstract:: Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...
Resource Type:: Dissertation
Full Text:: the burden-of-proof on the chemical supplier to demonstrate substance health and safety, while in

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Creator:: Momoda, Tracey S.
Abstract:: Rainbow trout (Oncorhynchus mykiss) experience a variety of stressors in their natural environment as well as in aquaculture that can have negative effects on their physiology. The effects of physiological stress and endocrine disruption have been well described in fish. However, there is a scarcity of information on the effects...
Resource Type:: Dissertation
Full Text:: expression and stress did not have an effect on EE induced gene expression in the heart of rainbow trout

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on May 25, 2006. Title: Environmental Contaminants

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: Page 39 Three dimensional graph showing the predicted effects of increasing 'PCB concentrations on

Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

Creator:: Ackerman, Luke K.
Abstract:: Many pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons are persistent, bio-accumulative, and toxic. These semi-volatile organic compounds (SOCs) can undergo atmospheric transport and deposition in cold, remote ecosystems. A better understanding of their accumulation in the fish of these ecosystems is important to better predict...
Resource Type:: Dissertation
Full Text:: Chemistry presented on March 29th, 2007. Title: Analysis of Semi-Volatile Organic Contaminants and Their

ScholarsArchive@OSU

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Chlordecone impaired biliary excretion : in vivo and in vitro correlates

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Oxidative stress and carcinogenesis in trout

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Congener-specific disposition of polychlorinated biphenyls in rainbow trout

Sex and life stage sensitivity of rainbow trout to xenoestrogens

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Alterations in mink reproductive physiology following exposure to coplanar and noncoplanar polychlorinated biphenyls (PCBs)

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Environmental Mixtures and Selected Health Outcomes in the US Population

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

The effects of environmental stressors on cardiac gene expression and contractility in rainbow trout (Oncorhynchus mykiss)

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Analysis of semi-volatile organic contaminants and their accumulation in remote aquatic ecosystems of the western US

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search