Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Many economically important Pacific salmon fisheries along the west coast of North America are mixed-stock, recreational systems, in which managers strive to account for interactions between fish, anglers, and management policy while balancing fishery access against conservation of vulnerable stocks. Specific challenges facing fisheries managers include limited control over angling...
To determine if 6 weeks prior supplementation with vitamins E and C
could alleviate exercise-induced DNA damage, prevent lipid peroxidation and
inflammation, slow the rate of vitamin E utilization and/or attenuate muscle
damage, 22 subjects (11 females: 11 males) were studied during a 50 km (32
mile) ultramarathon. Subjects were...
The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...
Introduction. The study was conducted in response to a need
for systematic analysis of the practice of granting academic credits
for prior off-campus learning. It was stimulated by a commitment
to the goal of facilitating student development and an interest in the
theory that such development can be enhanced through...
Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...
Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
In order to assess the importance of RNA synthesis in the induction
and antibody-producing phases of immune responses, actinomycin
D was used to inhibit the primary and secondary in vitro immune
responses of mouse spleen cells against heterologous erythrocytes.
The presence of actinomycin D (0.1 or 0.125 μg /ml) throughout...
Cellulolytic enzymes capable of efficiently degrading crystalline cellulose are a
complex mixture of endo- (endoglucanases) and exo-acting (cellobiohydrolases)
enzymes. One approach to separating these enzymes is affinity chromatography. A new
ligand, p-aminophenyl l-thio-β-D-cellobioside (APTC), is introduced for this purpose.
The property of APTC in affinity chromatography is demonstrated using Trichoderma...
Two light sensitive mutants of the green alga Scenedesmus obliquus strain D₃ have been characterized. The photodynamic nature of their sensitivity has been established, the subchloroplast site of photodamage has been investigated, and their noncarotenogenic character has been verified. The two mutants possess several similarities, although mutant L. S. -41...
The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Partial reactions of photosynthesis were examined in the wild
type strain and six photosynthetic mutants (8, 11, 26, 40, 50, a') of
Scenedesmus obliquus, strain D₃. A reproducible procedure for the
isolation of active chloroplast fragments from Scenedesmus was
developed. Several chloroplast reactions were examined, as well
as two in...
This paper develops an equation, from an heuristic set of assumptions,
which describes the axial current, leakage current, resultant
electric field, and resultant earth potential occurring when
a pipeline buried within a resistive earth is subjected to a distributed,
primary, axial, electrostatic field produced from a high-voltage, direct-current (HVDC) power...