Index Catalog // ScholarsArchive@OSU

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: EFFECT OF FOOD AND TABLET AGE ON THE RELATIVE BIOAVAILABILITY AND PHARMACODYNAMICS OF TWO TOLBUTAMIDE

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: , Tolbutamide and Pharmacokinetics-Toxicities of Thenophylline Injections in Pigs AN ABSTRACT OF THE THESIS OF

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: physiological role for that enzyme has been defined, use of the term cholinesterase assumes AChE unless

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: supplementation are its estrogenic effect as seen in trout and its ability to induce cytochrome P45 Os involved

Terminal oxidation pathways in Acetobacter suboxydans

Creator:: Kitos, Paul Alan
Resource Type:: Dissertation
Full Text:: . . . . . . . . . . . . . , . 64 1. pH Effect on aueose Oxidation . . . 6 2. Nuoleotide 3pecificity of G-o-P Dehydrogenase and

Certain physiological and pharmacological effects of radiation on rabbits

Creator:: Wagelie, Edwin Gan
Abstract:: Data were taken, following irradiation exposure to 100r and 300r cumulative dose, on 89 rabbits of three breeds that vary greatly in body size. Hematological, intestinal motility, and ear vascularity examinations were performed. Least square estimates have been obtained and an analysis of variance has been conducted in order estimate...
Resource Type:: Dissertation
Full Text:: Certain Physiological and Pharmacological Effects of

Use of radiation resistant organism as a protectant from lethal effects of irradiation in mice

Creator:: Kilbourn, Joan Priscilla Payne
Resource Type:: Dissertation
Full Text:: irradiation protected some of them from a lethal dose of irradiation. The effect of extracts from the

A metabolic function of selenium, assessed with rat liver homogenates

Creator:: Bull, Richard Charles
Abstract:: In three separate trials rats were fed either a basal diet deficient in selenium and vitamin E or the same diet supplemented with one or both of these factors. In addition to these treatments in two of the trials, ethoxyquin was included to provide adequate lipid antioxidant protection and to...
Resource Type:: Dissertation
Full Text:: beneficial effect upon reproduction in the rat. Somewhat later Poley et al. (1941), also conducting a

Effects of radiation on selection progress in mice

Creator:: Womack, James Ernest
Abstract:: The effects of x-irradiation on quantitative genetic traits was investigated by comparing the response of irradiated mice to selection for litter size and 28-day weight with the response to selection for the same two traits in non-irradiated lines. Irradiated lines were maintained at three levels of x-irradiation, 25 r, 50...
Resource Type:: Dissertation
Full Text:: interaction of genetic and physiological factors was assumed to be responsible for the reduced fertility

Manganese absorption by barley roots

Creator:: Maas, E. V. (Eugene Vernon), 1936-
Abstract:: An investigation of Mn uptake by five-day-old excised barley roots revealed that a metabolically-mediated process was involved. In short-term experiments, the rate of Mn absorption was comparable to that of the macronutrient cations. Like other metabolically absorbed cations, the Mn absorption rate was a direct function of the ambient concentration...
Resource Type:: Dissertation
Full Text:: studied, Li alone had a pronounced stimulatory effect while Na, K and Rb markedly reduced the absorption

Effects of radiation on selection progress in mice

Creator:: Womack, James Ernest
Abstract:: The effects of x-irradiation on quantitative genetic traits was investigated by comparing the response of irradiated mice to selection for litter size and 28-day weight with the response to selection for the same two traits in non-irradiated lines. Irradiated lines were maintained at three levels of x-irradiation, 25 r, 50...
Resource Type:: Dissertation
Full Text:: interaction of genetic and physiological factors was assumed to be responsible for the reduced fertility

Influence of dietary selenium on the distribution of tritium-labeled vitamin E in the rate

Creator:: Cheeke, Peter R.
Abstract:: A series of four trials were conducted to determine the influence of selenium supplementation of a selenium- and vitamin E-deficient basal diet on the absorption, excretion, tissue distribution and placental transfer of a single dose of tritium-labeled α-tocopherol in the rat. In the first trial, the effect of supplementation of...
Resource Type:: Dissertation
Full Text:: the rat. In the first trial, the effect of supplementation of the basal diet with 1. 0 ppm selenium

The effect of dimethyl sulfoxide (DMSO) on the radiosensitivity of the rough-skinned newt (Taricha granulosa)

Creator:: Lappenbusch, William L.
Abstract:: More than 2,000 male newts were collected during the summer and maintained unfed at 10°C both pre- and post-irradiation. Exposures ranging up to 30 kR were given with 300 kVp X-rays and ⁶⁰Co gamma rays. Half of the newts were injected (I. P.) with 15 g DMSO/kg (the maximum sublethal...
Resource Type:: Dissertation
Full Text:: The effect of dimethyl sulfoxide (DMSO) on the

A study of the relationship of the use of various drugs to the visual-motor performance of college students

Creator:: Antone, Eugene Joseph, Jr.
Abstract:: The purpose of the study was to compare the visual-motor performance of college students who reported ingestion of certain drugs with those college students who reported no drug ingestion. The study drugs included the following drugs or groups of drugs: tobacco, alcohol, marijuana, LSD, mescaline, barbiturates, and amphetamines. A total...
Resource Type:: Dissertation
Full Text:: or psychoneuroses. Chronic Toxic Reactions: An adverse psychological or physiological reaction to

Effects of x-irradiation on DNA synthesis in salivary gland cells of Drosophila hydei

Creator:: Wong, Patrick Tin-Choi, 1942-
Abstract:: The effect of X-irradiation on DNA synthesis in larval salivary glands of Drosophila hydei was studied using the technique of liquid scintillation spectrometry and autoradiography. DNA synthesis in salivary glands of synchronized larvae was measured at successive stages of third instar development by in vitro uptake of ³H-thymidine for a...
Resource Type:: Dissertation
Full Text:: Paul A. Roberts The effect of X-irradiation on DNA synthesis in larval salivary glands of Drosophila

Temperature and the bioenergetics of Cichlasoma bimaculatum

Creator:: Sethi, Hari Singh
Abstract:: One means of evaluating the temperature requirements of an animal is to determine changes temperature causes in the uses and losses of energy and materials in the food the animal consumes. To develop energy budgets for cichlids (Cichlasoma bimaculatum) at different temperatures (20, 24, 28, 32 and 36 C) data...
Resource Type:: Dissertation
Full Text:: determines the limits within which the animal is free to perform. Some of the pertinent physiological

The uptake, retention, and distribution of ⁶⁰Co, ⁶⁵Zn, ⁸⁵Sr, and ¹³¹I in the rough-skinned newt (Taricha Granulosa) : A radio-ecological study

Creator:: Valett, Bryan Batson
Abstract:: The uptake, retention, and distribution of ⁶⁰Co, ⁶⁵Zn, ⁸⁵ Sr, and ¹³¹I was examined in the Rough-Skinned Newt (Taricha granulosa). Each of these radionuclides is a possible contaminant of the freshwater environment and, thus, is of importance in radioecology. The newts were maintained singly at 10° C in an unfed...
Resource Type:: Dissertation
Full Text:: form complexes with organic materials. Thus, cobalt is potentially useful in physiological processes

Pulmonary function of male cigarette smokers compared with lifetime noncigarette smokers

Creator:: Barr, Robert Douglas
Abstract:: The pulmonary function scores of 250 male cigarette smokers were compared with 406 lifetime nonsmokers. A Stead-Wells spirometer was used to obtain forced vital capacity, forced expiratory flow, forced mid-expiratory flow, and forced expiratory volume. All individuals included in the sample were between. the ages of 20 and 49 years....
Resource Type:: Dissertation
Full Text:: American Physiological Society for lung volumes and for various phases of pulmonary research. Pulmonary

Histogenesis of fetal rat lung and liver after x-irradiation in organ culture and in utero

Creator:: Vogt, Judith C.
Resource Type:: Dissertation
Full Text:: Radiation Studies on Lung Cultures 36 Properties of Connective Tissue 38 Properties of Collagen 41 Effect of

Effects of dieldrin on the intrinsic rate of increase of the guppy, Poecilia reticulata Peters

Creator:: Roelofs, Terry Dean
Resource Type:: Dissertation
Full Text:: increase becomes more of a physiological parameter, the value of which is de- pendent upon existing

ScholarsArchive@OSU

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Terminal oxidation pathways in Acetobacter suboxydans

Certain physiological and pharmacological effects of radiation on rabbits

Use of radiation resistant organism as a protectant from lethal effects of irradiation in mice

A metabolic function of selenium, assessed with rat liver homogenates

Effects of radiation on selection progress in mice

Manganese absorption by barley roots

Effects of radiation on selection progress in mice

Influence of dietary selenium on the distribution of tritium-labeled vitamin E in the rate

The effect of dimethyl sulfoxide (DMSO) on the radiosensitivity of the rough-skinned newt (Taricha granulosa)

A study of the relationship of the use of various drugs to the visual-motor performance of college students

Effects of x-irradiation on DNA synthesis in salivary gland cells of Drosophila hydei

Temperature and the bioenergetics of Cichlasoma bimaculatum

The uptake, retention, and distribution of ⁶⁰Co, ⁶⁵Zn, ⁸⁵Sr, and ¹³¹I in the rough-skinned newt (Taricha Granulosa) : A radio-ecological study

Pulmonary function of male cigarette smokers compared with lifetime noncigarette smokers

Histogenesis of fetal rat lung and liver after x-irradiation in organ culture and in utero

Effects of dieldrin on the intrinsic rate of increase of the guppy, Poecilia reticulata Peters

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search