DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Ice cores are considered the gold standard for recording past climate and biogeochemical changes. However, gas records derived from ice core analysis have until now been largely limited to centennial and longer timescales because sufficient temporal resolution and analytical precision have been lacking, except during rare times when atmospheric concentrations...
Physicists who study semiconductor devices are fascinated by the fundamental limits of device performance. From the sub-threshold swing of transistors to the power conversion efficiency of photocells, performance is limited by the electronic structure of the materials used to build them. To surpass traditional device limits, we must turn to...
Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Two forest management objectives being debated in the context of federally managed landscapes in the US Pacific Northwest involve a perceived trade-off between fire restoration and C sequestration. The former strategy would reduce fuel (and therefore C) that has accumulated through a century of fire suppression and exclusion that has...
Individuals who have been traumatized have the opportunity to experience posttraumatic growth, conceptualized as positive changes that result from navigating highly challenging life circumstances (Tedeschi & Calhoun, 2004). The current model of posttraumatic growth (Calhoun, Cann, & Tedeschi, 2010) is based solely on cognitive-emotional processing yet by examining the role...
A 22 ha, 1S yeas old, diked permanent pasture in the Salmon River estuary in Lincoln County, Oregon, was chosen for a study to determine the potential for natural salt marsh restoration with dike breaching. Two undiked fragments of relatively undisturbed salt marsh, one at each end of the study...
Quick and accurate measurements of nanoparticles have important applications in biology, environmental and non-proliferation areas. Calculation of isotopic ratios, particularly in special nuclear materials, has relied on integration of nanoparticle counts and limited the capability of counting minor isotopes. Rapid transient detection method of nanoparticles has demonstrated the effectiveness of...
Multiagent learning with cooperative coevolutionary algorithms is a critical area of research, and is relevant to many real-world applications including air traffic control, distributed sensor network control, and game-theoretic applications such as border patrol. A key difficulty in multiagent learning is the credit assignment problem, where the impact of each...
This investigation has as its purpose: (1) to identify present
student personnel practices in evening community college programs,
(2) to identify student personnel practices considered "desirable" or
"undesirable" in evening community college programs, and (3) to
develop student personnel service guidelines for an evening community
college program.
Securing and Treating...
Quercetin (3, 3', 4', 5, 7-pentahydroxyflavone) reacts with hexavalent
molybdenum, tungsten and chromium to form chelates soluble
in an ethanol-water medium. This color reaction has been investigated
with a view to its possible application in the spectrophotometric
determination of trace amounts of these metals.
In the development of the method,...
Recent estimates indicate that over 50% of gay men acquire HIV from their
main sexual partners while in their relationship (Sullivan et al., 2009). Despite this
statistic, the majority of research has focused on individual factors as predictors of
unprotected anal intercourse (UAI) and not on relationship factors. The few...
The move from hazardous waste management to pollution
prevention is viewed as a paradigm shift in American
industry. Pollution prevention involves source reduction to
reduce the amount of hazardous waste that is generated, and
recycling of those wastes that cannot be prevented within
the production process. The first piece of...
The shortage of physicians serving rural communities is well documented. To address the rural shortage, medical schools have developed extracurricular programs, called rural health tracks, with an intent to foster medical students’ interest in serving rural communities. While there has been some research about the effects of these tracks, almost...
In nanoscale materials, the Coulombic interaction between electrons are stronger than in bulk materials. These stronger interactions, caused by confinement and reduced dielectric screening, have interesting consequences for light-matter interactions. In carbon nanotubes (CNTs), strong interactions can enhance the impact ionization process, and thus assist photocurrent generation in CNTs. Conversely,...
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...
Increased variability of rainfall and flow from climate change has the potential to stress existing transboundary water sharing agreements and make meeting the needs of all riparians difficult. Water treaties have been theorized as valuable tools for mitigating conflict in times of climate stress, but the relationship between the design...
Community colleges are in a strategic position to meet the growing demands for educating a population that is in a dynamic state of change, a population that is becoming more diverse with each passing year. A diverse population and other critical issues have created a new challenge for community colleges....
The concentration of ascorbic acid in the plasma was determined on
four levels of ascorbic acid intake for seven day periods in 1946-47 and
on three levels of ascorbic acid intake for ten day periods in 1947-48.
The subjects, eight girls and eight boys, were 16 to 19 year old...
L. C. Dunn (1893-1974) spent most of his scientific career conducting research in
developmental genetics as a member of the Zoology Department at Columbia
University in the City of New York. He had an accomplished scientific career
researching mutations in mice, which earned him respect from other geneticists and
scientists....
Phospholipase C-Jβ (PLCβ) is an important effector enzyme in G-protein-coupled
signaling pathways. Activation of PLCβ by Gα and Gβy subunits has been fairly well
characterized, but little is known about other protein interactions that may also
regulate PLCβ function. A yeast two-hybrid screen of a mouse brain cDNA library
with...
The purpose of this study was to determine if
students' school-related attitudes are significantly
affected by teacher classroom discipline management based
upon concepts contained in Judicious Discipline: A Constitutional
Perspective for School Rules (Gathercoal, 1986).
The data relative to student school-related attitudes
of elementary, middle, and high school students toward...
Prostaglandin F₂α (PGF₂α), a stimulatory hormone of luteal oxytocin
secretion, is known to activate protein kinase C (PKC); however, the
intracellular signals that promote exocytosis of oxytocin remain to be
elucidated. Myristoylated alanine-rich C kinase substrate (MARCKS), a
protein specifically phosphorylated by PKC, crosslinks actin filaments
associated with the inner...
The purpose of this study of the life and career of Dr. Carl
Leonard Anderson was to recount his professional contributions to
the field of health and relate these to public health and health education. The major emphasis of this study concerned Dr. Anderson's
professional life.
The accomplishment of the...
Oomycete and fungal pathogens threaten food, fiber, and forests around the world. With climate change, these pathogens are expected to emerge more frequently. Evolution can facilitate their emergence through mechanisms such as mutations that change or expand host range. Characterizing evolutionary mechanisms in plant pathogens will contribute to our ability...
Cellular sets in the Hilbert cube are the intersection of nested sequences of normal
cubes. One way of getting cellular maps on the Hilbert cube is by decomposing the Hilbert
cube into cellular sets and using a quotient map. By using a cellular decomposition of the
Hilbert cube, an example...
Vitamin C is an essential component of the human diet. Uptake of vitamin C in the cell is regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 (encoded by the SLC23A1 gene) is expressed in the colon, liver and kidney, where it plays a vital role in determining...
Ecology is focused on understanding how organisms interact with each other and their environments, across ecological, spatial, and temporal scales. Thus, understanding how processes and patterns of ecological systems change across space and time is a principle goal for conservation biologist globally. While many approaches exist for investigating the changing...
Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Consider the c- sample testing problem with null hypothesis H[subscript]o : F₁(x) = ... = F[subscript]c(x), where F[subscript]j(x), j = 1 ..., c, represent
absolutely continuous distribution functions for failure distributions.
Furthermore, consider arbitrarily (right) censored samples, which
may arise from putting the (censored) experimental units on test at
different...
Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Bromoalkoxylation of dihydropyran with bromine and 1-borneol, followed by dehydrobromination and epoxidation, afforded trans-2-1- bornyloxy-3,4-epoxytetrahydropyran as a major product. This was treated with sodium phenylselenide to give a 1:1 mixture of (2R,3R,4R)- 2-1-bornyloxy-3-hydroxy-4-phenylselenotetrahydropyran and its (2S,3S, 4S) diastereomer. Elimination of the selenoxide, derived from oxidation of the former with hydrogen...
DNA microarray technology is a powerful tool for analyzing patterns in gene expression data for thousands of genes. Due to a number of systematic variations in microarray experiments, the raw gene expression data is often obfuscated by undesirable technical noises. Various normalization techniques were designed in an attempt to remove...
Intimate partner violence (IPV) is a prevalent issue that impacts individuals around the world. Mental health professionals need comprehensive and inclusive IPV training to support victims/survivors well. The IPV literature posits several concerns surrounding the quality of IPV training that counselors-in-training (CITs) receive. Obtaining an understanding in how master’s level...