A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) that signifies the...
The first reported observation of hemoglobin association
with a plasma protein was made by Polonovski and
Jayle in 1938. Since that time, countless investigators
have contributed to the characterization of the hemoglobin-
binding plasma protein, haptoglobin. Haptoglobins
have been found in many mammals, including humans and in
various birds. However,...