Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic granulomatous enteritis that plagues domestic and wild ruminants globally. During the silent stages of Johne’s disease, infected animals intermittently shed bacteria for years prior to clinical diagnosis during advanced disease stages. This strategy allows MAP to...
Toxin production by cyanobacterial harmful algal blooms (cyanoHABs) in freshwater systems has lasting ecological and human impacts. Nutrients, light availability, hydrology, and microbial community composition impact the frequency and intensity of toxic cyanoHABs. Climate change will exacerbate toxic cyanoHABs, making real time and predictive monitoring a vital tool for managing...
Over time, Open Source Software (OSS) has become indispensable in the creation and upkeep of software products, serving as the fundamental building block for widely used solutions in our daily lives, including applications that enable communication, entertainment, and productivity. A sustainable OSS ecosystem is one that attracts and retains a...
Vortical structures are the driving mechanism of transition to turbulence in porous media requiring adequately resolved observations along with analysis of the scale and energy of flow within the pores. Of specific interest is to understand the vortex dynamics, energy, and turbulent mixing and transport properties in the scale of...
We believe concreteness, direct manipulation and responsiveness in a visual programming language increase its usefulness. However, these characteristics present a challenge in generalizing programs for reuse, especially when concrete examples are used as one way of achieving concreteness. In this thesis, we present a technique to solve this problem by...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....