Index Catalog // ScholarsArchive@OSU

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation
Full Text:: my committee members Dr Oleh Taratula, Dr Mark Christensen, Dr Arup Indra and Dr Julie Greenwood

Xanthohumol, a flavonoid from hops (Humulus lupulus) : in vitro and in vivo metabolism, antioxidant properties of metabolites, and risk assessment in humans

Creator:: Yilmazer, Meltem
Abstract:: Reported here is an investigation to determine the in vitro and in vivo metabolism of xanthohumol (XN). XN is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of beer, the major dietary source of prenylated flavonoids. Recent studies...
Resource Type:: Dissertation
Full Text:: mentorship. I also thank Drs. David E. Williams, Jeff J. Jenkins, Catherine M. Neumann, and John M

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:: Cote, Brianna M.
Abstract:: Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
Resource Type:: Dissertation
Full Text:: THE DISSERTATION OF Brianna M. Cote for the degree of Doctor of Philosophy in Pharmaceutical

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: . Rueda 5 , Ihab M. Wahba 6 1 Department of Pharmaceutical Sciences, Oregon State University

Evaluation and use of a soil mineralizable nitrogen test to determine the fertilizer nitrogen needs of winter wheat grown in western Oregon

Creator:: Baloch, Dost M.
Abstract:: The assessment of optimum nitrogen (N) fertilizer need for winter wheat (Triticum aestivum L.) is important for economic and environmental sustainability. A comprehensive understanding of fertilizer N requirement depends on estimation of the quantity of N needed by the crop versus that supplied by soil. The objectives of this study...
Resource Type:: Dissertation
Full Text:: . Christensen and Dr. John Hart for their availability, interest and incredible guidance. I am also thankful

The role of ethanol and certain ethyl esters in the fruity flavor defect of Cheddar cheese

Creator:: Bills, Donald D.
Abstract:: During the course of ripening, Cheddar cheese frequently develops a flavor defect described as fruity. Recent work has indicated that the use of certain starter cultures ultimately results in the development of the defect as the cheese ages. The flavor compounds responsible for the defect, however, have not been elaborated....
Resource Type:: Dissertation
Full Text:: would also like to express my gratitude to the members of my Program Committee: Dr. M. W

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Creator:: Albarqi, Hassan Ahmad M.
Abstract:: Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Resource Type:: Dissertation
Full Text:: I hope the project goes from strength to strength. Many thanks to Drs. John Christensen, Adam

The Effects of the Flow Regime on Stream Channel Form and Processes

Creator:: Hempel, Laura A.
Abstract:: Numerous studies have explored how alluvial channel size and morphology are adjusted to different sediment and flow conditions, yet we still know very little about how and to what degree the flow regime controls channel form and processes. We use the term ‘channel form’ to refer to the size and...
Resource Type:: Dissertation
Full Text:: encouragement. I would also like to thank my committee members, Dr. John Buffington, Dr. Roy Haggerty, and Dr

Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

Creator:: Fan, Ying
Abstract:: This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Resource Type:: Dissertation
Full Text:: encouragement and financial support. I also would like to thank my committee members, Dr. J. Mark Christensen

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Creator:: Le, Uyen Minh
Abstract:: Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
Resource Type:: Dissertation
Full Text:: financial support. I would like to thank Dr. J. Mark Christensen, Dr. Rosita Proteau, Dr. Lisa Madsen, and

ScholarsArchive@OSU

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Xanthohumol, a flavonoid from hops (Humulus lupulus) : in vitro and in vivo metabolism, antioxidant properties of metabolites, and risk assessment in humans

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

The study of pharmacokinetics in a clinical environment

Evaluation and use of a soil mineralizable nitrogen test to determine the fertilizer nitrogen needs of winter wheat grown in western Oregon

The role of ethanol and certain ethyl esters in the fruity flavor defect of Cheddar cheese

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

The Effects of the Flow Regime on Stream Channel Form and Processes

Effect of pharmaceuticals and natural products on multidrug resistance mediatedtransport in Caco-2 and MDCKII-MDR1 drug transport models

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

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