Temperature influences the incidence of chemically induced cancer in fish,
with warmer temperatures being associated with higher cancer incidence. The
mechanisms of temperature-modulated chemical carcinogenesis in fish, however,
have not been described in detail. Therefore, one primary objective of this study
was increased understanding of how temperature-modulated genotoxicity of 7,12-...
Two Oregon reservoirs contaminated by different mercury
sources were compared for mercury distribution in sediment and
bioaccumulation by fish. The average mercury concentration in
the sediment of Cottage Grove reservoir (0.67 ± 0.05 μg/g dry
wt) was higher than for Dorena Reservoir (0.12 ± 0.01 μg/g dry
wt). Sediment mercury...
Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis
in mice and rats. To increase understanding of how chlordecone (CD), an OC
insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD
pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Factors that influenced the uptake, storage, and elimination of dietary quinoline by rainbow trout (Salmo gairdneri) were studied to obtain an understanding of the mechanisms affecting the bioaccumulation of dietary contaminants in teleosts. Rainbow trout readily absorbed ¹⁴C-quinoline from pelleted food (1% ration at 138 ug quinoline/g food) and most...
Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Female mink (Mustela vison) are highly sensitive to polychlorinated biphenyl (PCB)-induced reproductive impairment. The goal of this research was to develop a better understanding of the mechanism of PCB-induced effects on female mink, mink embryos, and surviving mink kits. Anestrous, juvenile female mink and pregnant, adult mink were exposed to...
Effects of diet on food energy utilization by grass
carp fed aquatic plants or formulated diets with varied
lipid sources and levels are presented in three
manuscripts. Significant effects of diet on food
consumption, digestion, growth and muscle fatty acid (FA)
composition of fingerling diploid grass carp fed aquatic
macrophytes...