The interaction of skeletal muscle phosphofructokinase
with a variety of acidic proteins including calmodulin and
troponin C and with nucleic acids (RNA and DNA) is manifest
in a reversible, time-dependent loss of catalytic activity.
The inactivation is affected by a number of factors.
Substrates (fructose-6-phosphate and ATP), positive
effectors (fructose-2,6-bisphosphate,...
This thesis examines the interconnection between the in vitro and in
vivo phosphorylation of rabbit muscle phosphofructokinase. The first goal
of the project was to show whether a novel site of rabbit muscle
phosphofructokinase that is subject to in vitro phosphorylation, serine 376,
may also become phosphorylated in vivo. Evidence...
Growing awareness and concern within society over the use of and reliance on fossil fuels has stimulated research efforts in identifying, developing, and selecting alternative energy sources and energy technologies. Bioenergy represents a promising replacement for conventional energy, due to reduced environmental impacts and broad applicability. Sustainable energy challenges, however,...
This dissertation combines volcanological research of three convergent continental margins. Chapters
1 and 5 are general introductions and conclusions, respectively. Chapter 2 examines the spatiotemporal
development of the Altiplano-Puna volcanic complex in the Lípez region of southwest Bolivia, a locus of a
major Neogene ignimbrite flare- up, yet the least...
Kinetics of cell division in the intestinal epithelial proliferative cells (cell nests) of the rough-skinned newt, Taricha granulosa, were studied using tritiated thymidine autoradiography and the mitotic arresting properties of colcemid. Percent labeled mitoses (PLM) curves were drawn from the autoradiographic data from two separate experiments in which the newts...
Rising global temperatures are having lasting effects on mountain snow environments in the form of diminishing snowpacks, shorter accumulation seasons, and shifts in meltwater timing. Seasonal snowpack is a vital source of water for natural and human systems. In the forested mountain landscapes of the Pacific Northwest seasonal snowmelt feeds...
Marine sediments contain an abundance of methane that is biologically produced
and plays a significant role in the global carbon cycle. Microbes responsible for the
carbon cycle in marine sediments, and the processes that they carry out, need to be
characterized in order to fully understand the role of this...
Marine sediments are one of the largest habitats for microbial life on earth. These microorganisms play critical roles in biogeochemical cycling both within the subsurface and between the sediment and water columns. However, microbial communities in sediments are highly heterogeneous and the factors defining microbial community structure and metabolic function...
Nursery-grown seedlings are critical for attaining reforestation and restoration success in many ecosystems, including mixed-conifer forests in the Northwest, which is the native range for Douglas-fir (Pseudotsuga menziesii). Seedling establishment after planting depends on coordinated responses in seedling growth, physiology, and hydraulic function. The chapters in this dissertation review growth...
Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...