Genomic instability underlies diseases of unregulated cell growth that result in
cancers and developmental abnormalities in humans. Similar genome destabilizing
mechanisms are used to create genetic variety in crops for use in breeding and trait
development. Errors that occur during DNA replication may cause mutations if
they are not corrected...
Maintaining genome integrity is essential for an organism, as mutation
accumulation can lead to cancer, reduced fitness, and heritable diseases in offspring.
Therefore the study of mutations, how they are induced, and how they are prevented is
vital. Biomonitor systems are useful for understanding the relevant biological effects
of a...
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JohnB. Hays
Maintaining genome integrity is essential for an organism, as mutation
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...
NCRP report No.160 states that medical exposure increased to nearly half of the total radiation exposure of the U.S. population from all sources in 2006 (NCRP 2009). Part of this increase in exposure is due to the rise in nuclear medicine procedures. With this observed growth in medical radionuclide usage,...