Transition metal oxides are an important class of materials for the wide variety optical, electrical, dielectric, magnetic, and thermal properties observed. Their unique structure-property relationships allow for property tuning and often provide insight into the fundamentals of chemistry. The work in this thesis was focused on the design, synthesis and...
We examine the interactions and feedbacks between bathymetry, waves, currents, and
sediment transport. The first two pro jects focus on the use of remote sensing techniques
to expand our knowledge of the nearshore. Due to the plethora of snap-shot data that is
available from satellites and their distribution via Google...
Production of the host selective toxin victorin is causal to pathogenesis of Cochliobolus victoriae on oats. The dominant Vb gene confers oat sensitivity to victorin, and is genetically inseparable from Pc2, which confers resistance to Puccinia coronata f. sp. avena. Victorin induces apoptotic-like cell death, and cell death is a...
Preliminary toxicity studies of BCNU in rats revealed that significant
prolongations of pentobarbital hypnosis were associated with
all doses employed. Investigations were undertaken to determine the
underlying mechanism responsible for this observed effect. Studies
on the in vitro metabolism of pentobarbital by hepatic microsomes
of BCNU-treated animals demonstrated that significant...
Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...