Two epidemiological studies, designed to expand our knowledge of morbidity and
mortality indicators concerning malaria and Bacillus Calmette-Guerin vaccination in the
Hospital Albert Schweitzer health district located in Central Haiti's Artibonite Valley, are
presented. The hospital serves a rural population of 190,000 in its 610 square mile
district. A large...
Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Eight foodborne pathogenic and spoilage Gram-positive bacteria were
evaluated for their spontaneous resistance frequencies to the peptide
antimicrobial nisin. In brain heart infusion (BHI) medium, nisin resistance
frequencies were in the range of l06 to l08 when exposed to nisin at
concentrations 2 to 4 times the minimal inhibitory concentrations....
The role that anthropogenic and natural habitats in estuaries play in long-term population trends for Oregon’s nearshore marine fishes is poorly understood, in part due to limited temporal sampling. One important nearshore marine group is northeastern Pacific rockfishes (Sebastes spp.), which are highly diverse, with around 96 documented species, and...
In this dissertation I explore the application of two novel modeling techniques for improving risk analysis of vector-borne disease and discuss their potential use in integrating environmental risk assessment that guides environmental and public health decisions. Techniques for analyzing risk have been considered inadequate due to a lack of understanding...
Connectivity of fish populations is a crucial question for fisheries conservation and the development of spatial management plans. Both adult and larval movement define the extent and direction of ecological and evolutionary overlap between geographic regions and, therefore, how we define stocks for management purposes. Within that context, my work...
Significant amounts of uncertainty owing to both modeling decisions and inherent randomness are present in simulating the material and geometric nonlinear response of structural systems to extreme loading. Computing the sensitivity of structural response with respect to model parameters indicates which parameters have the largest affect on the response, which...
Climate change is expected to have both direct and indirect effects on water
resources. Hydrologic impacts of two indirect effects, vegetation density and stomata!
conductance, are evaluated for the American River, a 200 km² watershed in the
Cascade Range of Washington state. First, a set of distributed hydrology-biogeochemistry
model structures...
There is growing evidence that children develop science-related interests in early childhood, before they enter school, and that these interests may have long-term implications for science participation and achievement. Although researchers have made headway in describing interest development in the preschool years, little is currently known about the proximal processes...