The Newell Farmstead (35MA41) archaeological site lies in the heart of the French Prairie in the Willamette Valley in the Champoeg State Heritage Area, Oregon. The integrity and depth of deposition have made the Newell site a unique opportunity to look at activity areas and domestic life of early Euro-American...
The Champoeg townsite first developed due to its ideal settlement and trade location within the Willamette Valley, becoming the ‘legal birthplace of Oregon’ in 1843. However, by 1860 Champoeg’s significance had begun to decline, and in December of 1861 a devastating flood wiped out the townsite. Archaeological excavations took place...
My dissertation focuses on the evolutionary forces that have shaped the chemical signaling system of plethodontid salamanders. Pheromones mediate two phases of plethodontid reproduction: mate attraction prior to courtship and female persuasion during courtship. Substrate-borne chemical signals are believed to play an important role in mate attraction for these animals....
The tosylhydrazones of 2-heptanone, 4,4-dimethy1-2-
heptanone, 6-heptyn-2-one and 4,4-dimethy1-6-heptyn-2-
one were synthesized and decomposed under a variety of
reaction conditions: dry lithium and sodium salt pyrolyses,
sodium methoxide thermolyses in diglyme and photolyses of
the lithium salt in tetrahydrofuran. The saturated analogues
2-heptanone tosylhydrazone and its 4,4-dimethyl
isomer afforded the...
Studies towards the total synthesis of (-)-gymnodimine (1), a marine neurotoxin with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in a convergent approach to the advanced intermediate 315, containing the C3-C32 section of 1. Two synthetic routes were developed to construct the tetrahydrofuran subunit...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....