The mycosporins, formerly called P310's are secondary metabolites
of fungi closely associated with fungal reproductive processes that
require light. The structurally related iminomycosporins are found in
marine plants and animals and may also have functions related to
light. In this study, approaches toward the asymmetric synthesis of
the mycosporins are...
This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Water temperature influenced interactions between redside
shiners and juvenile steelhead trout (≥1+) in the field and the
laboratory. Distribution of the two species within various habitats
was determined in three streams with different water temperature
regimes. The range of habitats occupied by trout in allopatry at
cool temperatures and at...
The purposes of this study were to determine which research tasks
were necessary to the job descriptions of public school
administrators, secondary and elementary teachers; what task clusters
could be identified for college and university curriculums; what
differences existed between sample groups.
The instrument was validated through the Delphi technique....
To identify factors limiting 'Candidatus Pelagibacter ubique' maximum cell density and growth rate in pure culture on seawater, the genome sequence of 'Cand. P. ubique' was analyzed, culturing experiments with organic and inorganic nutrient additions were made, and radiotracer uptake experiments were performed. The genome was sequenced, custom data mining...
Nutrient losses of the biologically responsive anions, nitrate and bicarbonate together with the major cations, were monitored on 14 small watersheds in Oregon's Coast Range and evaluated in relation to management-induced disturbance. Mixed forests of Douglas-fir and red alder had dominated these high-nitrogen sites prior to treatment. A paired-watershed experimental...
This thesis describes a study of the synthesis, stereochemistry,
and reactivity of cobalt(III) cysteinato (CyS) and related thiolato complexes.
The preparation of [Co(en)₂CyS]⁺ resulted in a product solution
containing a mixture of diastereomers in the ratio 2.3:1 (Δ:A). The isomers were separated by ion exchange chromatography, and
their absolute configurations...
The first part of this thesis describes a study of the
characteristics of oxidation of a 1:2 iron(III):thiolate system in
methanolic solution and in water. This system was investigated as a
potential analog for the cysteine- and cysteamine-dioxygenase catalyzed
0₂-oxidation of cysteine and cysteamine, respectively, to the
corresponding sulfinic acids....
