Learning latent space representations of high-dimensional world states has been at the core of recent rapid growth in reinforcement learning(RL). At the same time, RL algo- rithms have suffered from ignored uncertainties in the predicted estimates of model-free or model-based methods. In our work, we investigate both of these aspects...
Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
During the eighteenth century, diagrams increasingly became an important aspect of scientific inquiry. Diagrams employed simplification as a strategy for representing complex information, played a role in standardizing scientific language, and served as instruments of reason to think through and communicate problems and findings in mathematics, physics, chemistry, astronomy, natural...
3D volume segmentation is a fundamental process in many scientific and medical applications. Producing accurate segmentations, in an efficient way, is challenging, in part due to low imaging data quality (e.g., noise and low image resolution), and ambiguity in the data that can only be resolved with higher-level knowledge of...
My work has focused on investigating synthetic organic reactions using applied computational methods. Non-covalent interactions are critical to catalysis, mechanism, and stereoselectivity, with the most prominent interaction for isothioureas being the S···O contact between the catalyst sulfur atom and the oxygen of the acyl group. A comprehensive joint experimental and...
The Pacific Northwest (Oregon and Washington in the United States and British Columbia in Canada) is one of the major producers of red raspberry (Rubus idaeus L.) and blueberry (Vaccinium corymbosum L.) in the world. The expansion of growing area with these crops has resulted in the emergence of new...
Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
In real networks, identifying dense regions is of great importance. For example, in a network that represents academic collaboration, authors within the densest component of the graph tend to be the most prolific. Dense subgraphs often identify communities in social networks. And dense subgraphs can be used to discover regulatory...
This dissertation has two objectives. The first objective is to determine where best to situate the study of mentoring (i.e. the 'making of scientists') on the landscape of the history of science and science studies. This task is accomplished by establishing mentoring studies as a link between the robust body...