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Filtering by: Committee Member Bermudez, Luiz Degree Level Master's Subject Antitubercular agents -- Toxicity testing

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Creator:

Singh, Priti B.

Abstract:

Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...

Resource Type:

Masters Thesis

Full Text:

to thank Dr. Luiz Bermudez for his scientific contributions and guidance that encouraged me to