Index Catalog // ScholarsArchive@OSU

Creator:: Engstrom, Arek Mackenzie
Abstract:: Nanoparticles (NPs), particles defined by their size in a single dimension (1-100 nm), are being increasingly incorporated into commercial and industrial products due to their high surface area to volume ratio that gives them unique properties, such as optical tunability and higher reactivity than their bulk counterparts. NPs can be...
Resource Type:: Masters Thesis
Full Text:: experimental development, and editing. Thank you to my committee members Dr. Joe Baio, Dr. Siva Kolluri, and

Creator:: Kasper, Katherine G.
Abstract:: The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
Resource Type:: Masters Thesis
Full Text:: appreciative of my committee members, Urszula Iwaniec, Russ Turner, and Siva Kolluri, for their interest in

Creator:: Kaller, Margo
Abstract:: Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
Resource Type:: Masters Thesis
Full Text:: as well! Dr. Siva Kolluri’s class on molecular therapeutics was a formative experience for my

Creator:: Sinnott, Brian D.
Abstract:: Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
Resource Type:: Masters Thesis

Creator:: Kaweesa, Elizabeth Namagoba
Abstract:: Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Resource Type:: Masters Thesis
Full Text:: Blakemore, Dr. Jane Ishmael, Dr. Kerry McPhail, Dr. Siva Kolluri and Dr. Taifo Mahmud for their insight

Creator:: Palmer, Amy L.
Abstract:: The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
Resource Type:: Masters Thesis

ScholarsArchive@OSU