Index Catalog // ScholarsArchive@OSU

EBB1, an AP2/ERF Transcription Factor, Promotes Transgenic Shoot Development in Populus

Creator:: Ree, Joseph
Abstract:: Recalcitrance to transformation makes genetic engineering of many valuable plants infeasible for practical use. Transitory host modification during transformation using transgenes offers a possible means of overcoming this obstacle. In prior work in our laboratory, the genes GA20ox7 and EBB1 were found to increase regeneration in vitro. In this project,...
Resource Type:: Undergraduate Thesis and Presentation

A Metabolomics Driven Investigation of Polyamine Metabolism During Adipogenesis

Creator:: Hughes, Taylor Neil
Abstract:: Obesity is achieved at the point where fat accumulation begins to exert deleterious effects on an organism. The human body accrues fat when there is an energy imbalance occurring, where caloric intake exceeds expenditure.Many anti-obesity drugs used in the past have had undesirable side effects, and currently there is a...
Resource Type:: Research Paper

Xanthohumol derivatives improve insulin sensitivity in obese mice

Creator:: Hay, Joshua
Abstract:: Metabolic syndrome, characterized by a collection of risk factors including abdominal obesity, insulin insensitivity, elevated plasma triglycerides, hypertension and low plasma high-density lipoproteins (HDLs), is a major contributing factor to the development of cardiovascular diseases and type II diabetes (T2D). Xanthohumol (XN), a flavonoid isolated from Humulus lupulus cones, has...
Resource Type:: Presentation

Vegetative effects of RNAi-suppression of the poplar homolog of LEAFY in the field

Creator:: Jacobson, Jeremy
Abstract:: Due to public and regulatory restrictions, genetic containment technology is critical for research and development of transgenic trees in forestry. A multi-year field trial demonstrated that the RNAi-LFY construct successfully induces sexual sterility in 6K10 poplar (Populus alba) without visible effects on vegetative development. However, its limited number of replicates...
Resource Type:: Undergraduate Thesis and Presentation
Full Text:: 0.955 Model lm lm gls gls gls gls gls gls gls gls Log Transformed N N N N N N N N N N 41 P-Value

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Creator:: Bratton, Daniel
Abstract:: The oilseed crop Limnanthes alba (white meadowfoam) is grown in Oregon. Methods were developed for the production of a liquid-based bioherbicide from meadowfoam seed meal (MSM). It was determined that glucosinolate-containing extracts of MSM can be combined with active-enzyme-containing liquid extracts of meadowfoam seed to form a fermented product rich...
Resource Type:: Undergraduate Thesis
Full Text:: n m p e a k a re a Ground Unground Fig 2. Extraction of GLN from ground vs. unground MSM

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Creator:: Stevens, Danielle M.
Abstract:: Carbonic anhydrases are ubiquitous enzymes that catalyze the reverse hydration and dehydration of carbon dioxide and bicarbonate respectively. A variety of tumors in humans show overexpression of human carbonic anhydrase II (HCA II) leading to an acidic breakdown of carbon dioxide into bicarbonate. While a variety of drug inhibitors exist,...
Resource Type:: Research Paper
Full Text:: phenylalanine with p-bromophenylalanine (pBrF) has a slight decrease in enzymatic activity while the exchange

Characterizing a Coupled Photodiode-LED System for Neuro-Sensing Applications

Creator:: Stevens, Gregg
Abstract:: I investigate the feasibility of a micron-sized biosensor designed to measure neural activity. The circuitry of the biosensor is composed of graphene, some photodiodes, and a light-emitting diode. Many of these biosensors would be injected into a subject’s brain, and when powered by near-infrared light, they would glow in response...
Resource Type:: Undergraduate Thesis
Full Text:: denoted as δp), not the total change in resistance (dR). The two are related by Equation 9: δp ≡ Δ

Characterizing the symbiotic interactions between Rhodococcus and plants

Creator:: Stevens, Danielle M.
Abstract:: Bacteria are critical to the health of eukaryotes and the ecosystems in which they persist. Some symbiotic interactions are mutualistic in which both microbe and host benefit from the partnership. Other interactions are parasitic, and the microbe typically benefits at a cost to the host. Rhodococcus is a genus of...
Resource Type:: Undergraduate Thesis
Full Text:: . J. Bacteriol. 176: 2492-2501. Dhandapani, P., Song, J., Novak, O., and Jameson, P. E. 2017

Phytochemical characterization of Fagonia indica and its effects on MCF-7 breast cancer cell line

Creator:: Kumbi, Yadano
Abstract:: Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health, particularly, anti-cancer properties. Certain Fagonia species contain various types of phytochemicals such as saponins, alkaloids, cardiac glycosides, flavonoids, terpenoids, and tannins. In this study, we investigated the phytochemical composition of a...
Resource Type:: Undergraduate Thesis
Full Text:: -treated), with p < 0.05 as the level of significance using GraphPad Prism 7.03. Acid hydrolysis of

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:: Sanchez, Karina M.
Abstract:: Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Resource Type:: Undergraduate Thesis
Full Text:: pathway where vitamin C ascorbylates and conjugates the hepatotoxic metabolite N-acetyl-p- benzoquinone

ScholarsArchive@OSU

EBB1, an AP2/ERF Transcription Factor, Promotes Transgenic Shoot Development in Populus

A Metabolomics Driven Investigation of Polyamine Metabolism During Adipogenesis

Xanthohumol derivatives improve insulin sensitivity in obese mice

Vegetative effects of RNAi-suppression of the poplar homolog of LEAFY in the field

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Characterizing a Coupled Photodiode-LED System for Neuro-Sensing Applications

Characterizing the symbiotic interactions between Rhodococcus and plants

Phytochemical characterization of Fagonia indica and its effects on MCF-7 breast cancer cell line

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

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