Index Catalog // ScholarsArchive@OSU

Transdermal Delivery of Atenolol to Cats

Creator:: Mohamed, Sumeia M.
Abstract:: This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ John M. Christensen This thesis describes in-vitro and in-vivo evaluation of a transdermal

Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

Creator:: Li, Wenjing
Abstract:: The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ John Mark Christensen The methodology to perform bioequivalence studies for prodrug

Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets

Creator:: Sartnurak, Soisurin
Abstract:: Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion...
Resource Type:: Dissertation
Full Text:: Formulation of Oral Ibuprofen Tablets Abstract approved: L. -,, , ..,-...--- John M. Christensen, Ph.D

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: Chulalongkorn University for full financial support throughout my study, and to Dr. John M. Christensen and Dr

Development of novel oral enteric-coated aquaculture vibrio vaccines

Creator:: Wong, George Kaon
Abstract:: An oral Vibrio vaccine for salmonids was developed. The vaccine was produced by spray coating lyophilized formalin-killed whole cells of Vibrio anguillarum (VA LS 1- 74) onto non-pareil sugar beads. Then methacrylic acrylic acid copolymer (Eudragit L-30D) was applied as an enteric protective coating. Using x-ray radiographic techniques, it was...
Resource Type:: Dissertation
Full Text:: Aquaculture Vibrio Vaccines Abstract approved: 114edaatecr 4for Privacy ohn M. Christensen, Ph.D. An oral

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Creator:: Ma, Lian
Abstract:: The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...
Resource Type:: Dissertation
Full Text:: : John Mark Christensen The first part of the dissertation is to evaluate the use of proposed and

Disposition of C H N O S in rats and three antiulcer agents in llamas

Creator:: Limsakun, Tharin
Resource Type:: Dissertation
Full Text:: Llamas Abstract approved: John Mark Christensen, Ph.D. The solubility and disposition of a new

Fish oral antigen delivery system development and optimization

Creator:: Zhang, Jia Ai (Allen)
Abstract:: Oral administration is the most practical way of vaccination of fish. It has advantages over intraperitoneal injection and immersion methods that include no stressful handling, no interference with routine fish husbandry and antigens can be delivered to the fish in their feed. An oral antigen delivery system was developed for...
Resource Type:: Dissertation
Full Text:: Optimization Abstract Approved: John Mark Christensen, Ph.D. Oral administration is the most practical

Pharmacokinetics of ampicillin, gentamicin, amikacin, and omeprazole in llamas

Creator:: Kasiwong, Srirat
Resource Type:: Dissertation
Full Text:: , Amikacin and Omeprazole in Llamas. Abstract approved: John Mark Christensen Ampicillin sodium and

1) Preparation of Acetaminophen Capsules Containing Beads Prepared by Hot-melt Direct Blend Coating Method 2) Pharmacokinetic Modeling and Monte Carlo Simulations in The Context of Additional Criteria for Bioequivalence Assessments 3) Pharmacokinetic Prediction of Levofloxacin Accumulation in Tissue and its Association to Tendinopathy

Creator:: Pham, Loan
Abstract:: The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
Resource Type:: Dissertation
Full Text:: Tendinopathy. Abstract approved: John M. Christensen The thrust of

ScholarsArchive@OSU

Transdermal Delivery of Atenolol to Cats

Application of Bootstrap Methods in Bioequivalence Studies for Oral Generic Prodrug Products

Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Development of novel oral enteric-coated aquaculture vibrio vaccines

Analysis of nonlinear pharmacokinetic systems and the nonlinear disposition of phenylbutazone in equine (horses)

Disposition of C H N O S in rats and three antiulcer agents in llamas

Fish oral antigen delivery system development and optimization

Pharmacokinetics of ampicillin, gentamicin, amikacin, and omeprazole in llamas

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