Index Catalog // ScholarsArchive@OSU

Crystal structures of DNA four-way junctions

Creator:: Eichman, Brandt F.
Abstract:: DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
Resource Type:: Dissertation

Controlling DNA packing in crystals

Creator:: Mooers, Blaine H. M.
Resource Type:: Dissertation

Studies on the hydrophobic effect and its contribution to the stability, crystallization, and helix packing of Z-DNA

Creator:: Kagawa, Todd F.
Abstract:: The studies presented here use the B- to Z-DNA transition and Z-DNA crystallization as model systems to determine the contribution of solvent interactions to macromolecular structures. The substituent groups of naturally occurring and modified nucleotide bases affect the hydration and thus the stability of right-handed B-DNA and left-handed Z-DNA. The...
Resource Type:: Dissertation

Design of B-form specific DNA binding oligonucleotide analogues : investigations of novel recognition moieties for triple helix formation

Creator:: Hogeland, Jane S.
Resource Type:: Dissertation

The bacteriophage P1 bof protein : a corepressor whose action can both negatively and positively affect phage gene expression

Creator:: Schaefer, Timothy S.
Resource Type:: Dissertation

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

Creator:: Georgel, Philippe, 1961-
Abstract:: The aim of this study was to gain more information about the interactions between DNA and the histone octamer during the process of transcription. This work used a pUC8 plasmid derivative that contained the core promoter region of the RNA polymerase I of Acanthamoeba castellanii, placed upstream of four repeats...
Resource Type:: Dissertation

Site-specific aflatoxin B₁ adduction of sequence-positioned nucleosome core particles

Creator:: Moyer, Richard A.
Abstract:: The question of how the presence of nucleosomal packing of DNA modifies carcinogen interaction at specific sites cannot be answered by studies on whole chromatin or bulk nucleosomes because of the heterogeneity of DNA sequences in the particles. This problem was circumvented by constructing nucleosomes that are homogenous in DNA-histone...
Resource Type:: Dissertation

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Creator:: Weitz, Stephen L.
Abstract:: Investigators have been studying an aggregate containing enzymes of deoxyribonucleoside triphosphate biosynthesis in T4-phage infected bacteria. They suggest that it behaves as an organized complex, efficiently channeling DNA precursors to the replication apparatus. Previous work has suggested that about 10 enzyme activities remain associated through several fractionation steps. This multi-enzyme...
Resource Type:: Dissertation

Properties and conformation of P-form DNA

Creator:: Zehfus, Micheal H.
Abstract:: Work is presented which explores the properties and nature of the P-form of DNA. Initially the P-form represented an unknown state of DNA which occurred when this molecule was in a solvent of 47.5% methanol, 5% water, and 47.5% ethanol, and which showed properties of both native and denatured conformations....
Resource Type:: Dissertation

DNA precu[r]sor compartmentation in mammalian cells : metabolic and anti-metabolic studies of nuclear and mitochondrial DNA synthesis

Creator:: Bestwick, Richard Keith
Abstract:: This dissertation describes an investigation of DNA precursor supply for mitochondrial and nuclear DNA synthesis in HeLa cells and Mouse L-cells. HeLa cells were used for the quantitation of cellular and mitochondrial deoxyribonucleoside triphosphate (dNTP) and ribonucleoside triphosphate (rNTP) pools and of changes in pools in response to treatment with...
Resource Type:: Dissertation

Hydrodynamic properties of homogeneous double-stranded DNA

Creator:: Kovacic, Roger Timothy
Resource Type:: Dissertation

Comparison of the reassociation and hybridization properties of the DNAs for several species of fish

Creator:: Gharrett, Anthony John
Abstract:: The genome composition and DNA base sequence homologies of several diverse species of fish were examined. The fishes were characterized from spectrophotometric studies of reassociation and hybridization of their DNAs and from the thermal stabilities of hybrid duplexes. Spectrophotometric studies indicated that repeated sequences comprise 35-40% of the genomes of...
Resource Type:: Dissertation

Deoxyribonucleic acid hybridization and plasmid studies in the genus Lactobacillus

Creator:: Sriranganathan, Nammalwar
Abstract:: Using thermal denaturation methodology, the nucleic acid base composition of deoxyribonucleic acid (DNA) isolated from type, neotype and stock strains of Lactobacillus species was determined. The genus was found to be heterogeneous in base composition, ranging from 33.1 to 50.0 moles % guanine plus cytosine (GC). Genus members fell into...
Resource Type:: Dissertation

Studies on the interaction of polylysine with deoxyribonucleic acid

Creator:: McKenzie, Raymond Leslie
Abstract:: The interaction of polylysine with DNA may be divided into two separate phenomena: the primary interaction involved in formation of a well-defined complex, and secondary interactions leading to aggregation of these complexes. Most studies on the interaction of polylysine with DNA have used techniques which measure properties of the aggregated...
Resource Type:: Dissertation

A partial characterization of the deoxyribonucleic acid found in the thoracic muscles of the tobacco hornworm moth (Manducta sexta)

Creator:: Hinds, Thomas Richard, 1944-
Abstract:: The DNAs (deoxyribonucleic acids) of the thoracic tissue of the tobacco hornworm, Manducta sexta, were studied by physical and chemical means. The adult moth was considered to be fully formed two days after emergence from the pupal case, as indicated by its ability to fly and the integrity of the...
Resource Type:: Dissertation

Properties of ribonucleic acid and deoxyribonucleic acid during developmental stages in B. cereus 569

Creator:: Wise, John Arnold, 1939-
Resource Type:: Dissertation

Deoxyribonucleic acid homology in the genus Lactobacillus

Creator:: Miller, Alexander, III
Resource Type:: Dissertation

Isolation and characteristics of the DNA from nuclear polyhedrosis virus

Creator:: Carnegie, John William
Abstract:: The genome of the nuclear polyhedrosis virus which infects the larvae of the tussock moth, the lepidopteran, Hemerocampa pseudotsugata, was isolated, identified as deoxyribonucleic acid, and characterized in terms of its physical and biological properties. An isolation procedure for the viral DNA was established which consisted of the following steps:...
Resource Type:: Dissertation

The interaction of polylysine with DNA as studied by polarization of flurescence

Creator:: Evett, Jay Fredrick
Abstract:: A fluorescent dye, 1-dimethylaminonaphthalene-5-sulfonyl chloride (dansyl chloride), was covalently bonded to polylysine. The dansyl tagged polylysine was complexed to DNA by gradient dialysis. The polarization and intensity of fluorescence of the dansyl and the turbidity of the complex were measured as a function of salt concentration for a variety of...
Resource Type:: Dissertation

The effect of Streptococcus lactis bacteriophage c2 DNA on the growth of Bacillus cereus

Creator:: Anderson, Gerry Charles
Resource Type:: Dissertation

The association of DNA with other cellular materials in Escherichia coli lysates

Creator:: Porter, Bruce Wallace
Abstract:: The association of other materials with DNA has been studied extensively in higher organisms and more recently in bacteria. However, investigation of these complexes in bacteria have for the most part been restricted to the study of a specific function this association may serve, or a specific kind of association....
Resource Type:: Dissertation

ScholarsArchive@OSU

Crystal structures of DNA four-way junctions

Controlling DNA packing in crystals

Studies on the hydrophobic effect and its contribution to the stability, crystallization, and helix packing of Z-DNA

Design of B-form specific DNA binding oligonucleotide analogues : investigations of novel recognition moieties for triple helix formation

The bacteriophage P1 bof protein : a corepressor whose action can both negatively and positively affect phage gene expression

Effects of nucleosomes on transcription by polymerase I in a reconstituted system

Site-specific aflatoxin B₁ adduction of sequence-positioned nucleosome core particles

Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

Properties and conformation of P-form DNA

DNA precu[r]sor compartmentation in mammalian cells : metabolic and anti-metabolic studies of nuclear and mitochondrial DNA synthesis

Hydrodynamic properties of homogeneous double-stranded DNA

Comparison of the reassociation and hybridization properties of the DNAs for several species of fish

Deoxyribonucleic acid hybridization and plasmid studies in the genus Lactobacillus

Studies on the interaction of polylysine with deoxyribonucleic acid

A partial characterization of the deoxyribonucleic acid found in the thoracic muscles of the tobacco hornworm moth (Manducta sexta)

Properties of ribonucleic acid and deoxyribonucleic acid during developmental stages in B. cereus 569

Deoxyribonucleic acid homology in the genus Lactobacillus

Isolation and characteristics of the DNA from nuclear polyhedrosis virus

The interaction of polylysine with DNA as studied by polarization of flurescence

The effect of Streptococcus lactis bacteriophage c2 DNA on the growth of Bacillus cereus

The association of DNA with other cellular materials in Escherichia coli lysates

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