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Filtering by: Committee Member Ho, P. Shing Remove constraint Committee Member: Ho, P. Shing Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.) Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

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  • DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

    Creator:
    Hooven, Louisa Ada
    Abstract:
    Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
    Resource Type:
    Dissertation
    Full Text:
    unwavering support. My appreciation is also extended to Dr. P. Shing Ho, Dr. Christopher K. Mathews, and Dr

  • Electron molecule interactions of amino acids and peptides

    Creator:
    Figard, Benjamin J.
    Abstract:
    Electron-biomolecule interactions are a biologically relevant field of study because there are several ion fragmentation techniques that have come to the forefront in mass spectrometric analysis that involve the interaction of charged peptides and free electrons. By studying the electron energies that cause fragmentation in neutral amino acids, amino acid...
    Resource Type:
    Dissertation
    Full Text:
    peptide substance P. For peptides with carboxylic acids on the C-terminus, z-1 ions were observed

  • Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

    Creator:
    Beverly, Robert L.
    Abstract:
    Premature birth interrupts the typical development of the human fetus, leaving the infant born with underdeveloped gastrointestinal and immune systems. Preterm infants have reduced stomach acidity, reduced digestive protease activity, more permeable intestinal membranes, impaired innate and adaptive immune response, and poor microbiome development. Due to these factors, preterm infants...
    Resource Type:
    Dissertation
    Full Text:
    research and neonatal care. I expressly thank my committee members–Dr. Donald Jump, Dr. Emily Ho, Dr

  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    , role modeling, and assistance. To my committee members – Drs. Emily Ho, Andy Karplus, Kathy