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Filtering by: Alternative title ssim WIRE'd Winter 2007 Remove constraint Alternative title ssim: WIRE'd Winter 2007 Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.) Rights Statement In Copyright - Educational Use Permitted Remove constraint Rights Statement: In Copyright - Educational Use Permitted

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  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
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    Dissertation
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    ..................................................................................... 39 2.1 Late endosomes are essential for mRNA transfection. (a) Schematic representation of Rab

  • Knowledge Appropriation and Inventive Productivity

    Creator:
    Choi, Yohan
    Abstract:
    Innovation is critical for firm growth and survival. Thus, how much value firms create and capture from their innovative activities has been an interest of scholars. This dissertation explores three important questions on this topic to which extant literature has paid little attention. First, I examine how the external threat...
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    Dissertation
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    - between trade secret protection and firm R&D productivity…… 39 3.2.4. The effect of trade secret

  • Applied economic strategies to evaluate policies and environmental outcomes: case studies from immigration and ecosystem services

    Creator:
    Natanson, Alexander D.
    Abstract:
    My dissertation title is, “Applied economic strategies to evaluate policies and environmental outcomes: case studies from immigration and ecosystem services.” The first two chapters of this dissertation concern the relationship between local immigration policies and societal welfare. The third chapter examines the impact of human activity on the environment and...
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    Dissertation
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    ......................................................................................................... 39 3.4 Results

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
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    Dissertation
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    -rich DNA. (A) Actinomycin D (4.1) was tested at 0.03, 0.10, 0.20, 0.40, 1.00, 2.00, and 3.00 µM. (B

  • Adolescent Suicide Through the Lens of 13 Reasons Why: A Corpus Based Study

    Creator:
    Ware Zooi, Rachel
    Abstract:
    With growing recognition of adolescence as the time in which suicidal thoughts and behaviors first occur, early identification and intervention systems in schools have become an international priority. Understanding and incorporating language indicators associated with the core psychological and interpersonal processes of adolescent suicidality could provide promising tools for school...
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    Dissertation
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    and a half times higher; and (d) causal explanation thinking style one and a half times higher

  • A socio-technical study on the improved characterization of stakeholder behaviors and stream temperature in design of watershed conservation practices for climate change adaptation

    Creator:
    Noa-Yarasca, Efrain
    Abstract:
    Characterizing stakeholder behavior when making decisions in watershed management is a great challenge for planners, not only because plans are associated with physical uncertainties but also because stakeholders’ behaviors are influenced by numerous factors. Since stakeholders’ decision-making is linked to multiple types of uncertainty, communication of uncertainty to stakeholders by...
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    Dissertation
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    like to single out Adriana D. Piemonti, Samuel Rivera, and Andrea Chiou for their active contribution

  • New Graphite Intercalation Chemistry with Alkaline Earth Metals

    Creator:
    Xu, Wei
    Abstract:
    Novel graphite intercalation compounds (GICs) and associated chemistry have been explored, specifically: (1) containing alkyl- substituted imidazolium cations; (2) a series containing alkaline earth metal (Mg, Ca, Sr, Ba) cations with ethylenediamine (en) co-intercalates; (3) showing reversible intragallery M-M bonding and (4) via electrochemical intercalation of Mg cations with potential...
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    Dissertation
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    ........................................................................................................39 2.4 Result and Discussion

  • Implementation Science in Teaching and Learning in Higher Education: A Mixed-Methods Study of the Utility Value Intervention in General Psychology Courses

    Creator:
    Soicher, Raechel N.
    Abstract:
    Despite the dissemination of comprehensive reviews and teacher-friendly resources describing evidence-based practices to improve student outcomes, the adoption of these practices is slow and inconsistent across instructors at colleges and universities. To help reduce this research-practice gap, I argue for the application of implementation science to teaching and learning research...
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    and Learning in Higher Education.…………………………………………...39 3. Distribution of Student Responses to

  • Emergent Properties of Animal Social Networks: Five Stories in Five Systems

    Creator:
    Devan-Song, E. Anne
    Abstract:
    Animals aggregate and interact in nonuniform and nonrandom patterns, which lead to group level characteristics that have important evolutionary and ecological consequences. Network analysis provides a useful conceptual framework for linking animal interactions at all scales from dyads to communities, to populations and ecosystems. Despite exciting theoretical and applied advances...
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    Dissertation
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    Historical Park, Yorktown, Virginia, USA in 2017. ................................................. 39

  • Transdermal Delivery of Atenolol to Cats

    Creator:
    Mohamed, Sumeia M.
    Abstract:
    This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
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    )……………………………………………………………………….…..39 1.8 Atenolol concentration versus time for formulation 6 (synthetic membrane