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Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: Pereira, Kathi Georgitis and Greg Jenkins were responsible for statistical analysis of data for all

Creator:: Tilton, Susan C.
Abstract:: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...
Resource Type:: Dissertation
Full Text:: Research Laboratory. I also thank Dr. Cliff Pereira for his advice and statistical support on these

Creator:: Oganesian, Aram
Abstract:: There is plenty of evidence from epidemiology studies supporting a link between certain components in the human diet and cancer incidence. It is estimated that 3-4 million annual cases of cancer could be prevented worldwide just by changing dietary habits. In parts of the world where vegetables and fruits constitute...
Resource Type:: Dissertation
Full Text:: procedures involving the initiation with the carcinogen. Dr. Cliff Pereira was responsible in statistical

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