Index Catalog // ScholarsArchive@OSU

Creator:: Will, Yvonne
Resource Type:: Dissertation
Full Text:: model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Creator:: Tirmenstein, Mark A.
Abstract:: Lipid peroxidation is believed to be an important process in the development of cellular injury. In addition to the degradation of biological membranes, increasing evidence indicates that lipid peroxidation can alter the structure and function of DMA. The present study examines the peroxidation of nuclear membranes and the capacity of...
Resource Type:: Dissertation
Full Text:: Studies on the glutathione dependent protection of the cell

Creator:: Erve, John C. L.
Abstract:: Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Resource Type:: Dissertation
Full Text:: and Proteins by S-(2-chloroethyl) glutathione and Characterization of Adducts by Mass Spectrometry

Creator:: Siller-Cepeda, Jorge H.
Abstract:: A rapid and sensitive HPLC method for quantifying both the reduced and oxidized forms of glutathione simultaneously in woody plant tissues was developed. This method was applicable to a variety of woody plant species and different tissues. Total glutathione content in the bark tissue of seven of the woody plant...
Resource Type:: Dissertation
Full Text:: quantifying both the reduced and oxidized forms of glutathione simultaneously in woody plant tissues was

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation
Full Text:: Nrf2 consequentially attenuates synthesis and steady state levels of liver glutathione (GSH

Creator:: Dixon, Brian M.
Abstract:: Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Resource Type:: Dissertation
Full Text:: (redox) environment, exemplified by the glutathione redox ratio (GSH:GSSG), is vital for both ER stress

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: increasing expression of GCL, the rate-limiting enzyme in glutathione synthesis, quercetin treatment also

ScholarsArchive@OSU