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Filtering by: Creator Terry, Michael D. Remove constraint Creator: Terry, Michael D. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.) Subject Transcription factors Remove constraint Subject: Transcription factors

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  • Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

    Creator:
    Bredeweg, Erin L.
    Abstract:
    Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
    Resource Type:
    Dissertation
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    :! ! ! ! ! ! ! ! ! ! ! ! ! ! Michael!Freitag! ! Fungi!are!capable!of!growth!on!a!wide!variety!of!carbon!sources,!both!living!and

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
    Resource Type:
    Dissertation
    Full Text:
    : Chrissa Kioussi Michael K. Gross The spatial and temporal patterning of

  • The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

    Creator:
    Kyrylkova, Kateryna
    Abstract:
    BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
    Resource Type:
    Dissertation
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    confident and successful woman Dr. Michael Freitag, Dr. John Fowler, and Dr. Siva Kolluri, my committee

  • Gene networks during cardiogenesis and skeletal myogenesis

    Creator:
    Ma, Hsiao-Yen
    Abstract:
    Organismal development requires a precisely orchestrated transcriptional program to correctly deploy genetic information into the genome. This process requires sophisticated gene regulatory networks at multiple spatial and temporal levels from early embryonic development to adult physiological conditions. Molecular differences that define cell types are set up during the pattern formation...
    Resource Type:
    Dissertation
    Full Text:
    . Hsiao-Yen Ma, Author ACKNOWLEDGEMENTS Dr. Chrissa Kioussi – Major Advisor Dr. Michael K

  • The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

    Creator:
    Shih, Hung Ping
    Abstract:
    Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
    Resource Type:
    Dissertation
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    designed research; Hung Ping Shih performed research; Hung Ping Shih, Michael K. Gross and Chrissa Kioussi

  • Transcriptional repression by CTIP2, a C2H2 zinc finger protein

    Creator:
    Topark-Ngarm, Acharawan Khamsiritrakul
    Abstract:
    CTIP2, a novel C2H2 zinc finger protein, is a transcriptional repressor that functions by at least two mechanisms. CTIP2 interacts with and stimulates transcriptional repression mediated by COUP-TF family members. CTIP2 also represses transcription independently of COUP-TF proteins by direct, sequence-specific DNA binding activity. CTIP2 has been implicated in lymphoid...
    Resource Type:
    Dissertation
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    , Dr. Theresa Filtz, Dr. Michael Schimerlik, and Dr. Mark Hoffman, for their guidance and

  • Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

    Creator:
    Luo, Ting
    Abstract:
    Metabolic syndrome is a problem affecting people around the world. In a number of studies, soy intake has been documented to possess antidiabetic and anticardiovascular effect. My project is focused on the impact of the intake of compounds found within soy, the isoflavones, their impact on metabolic syndrome symptoms, and...
    Resource Type:
    Dissertation
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    daidzein (WD+D) for 10 weeks. Surprisingly, intake of WD+G and WD+D significantly decreased food intake

  • Gene regulatory networks during muscle development

    Creator:
    Eng, Diana G.
    Abstract:
    Congenital myopathies are caused by heritable mutations in particular genes. Genes mutated in congenital muscular dystrophies often encode cytoskeletal proteins, which contribute to the shape and movement of cells. We would like to know how such molecular defects lead to the muscle weakness in patients. It is therefore important to...
    Resource Type:
    Dissertation
    Full Text:
    , Michael Gross and Chrissa Kioussi edited the chapter. Chapter 3: Diana Eng designed and performed the