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Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Creator:: Davis, Ralph Eugene, 1957-
Abstract:: Vaccinia virus infected monkey kidney cells had been previously shown to have an increased ribonucleoside diphosphate reductase (RR) activity. DNA from mutant virus resistant to hydroxyurea were digested with restriction endonucleases and were shown to have substoichiometric amounts of the Hind III F fragment. Additional information from Southern blotting experiments...
Resource Type:: Dissertation
Full Text:: THESIS OF Ralph Eugene Davis for the degree of _Qoctor of Philosophy in Biochemistry and Biophysics

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Creator:: Whitehead, Stephen S.
Resource Type:: Dissertation
Full Text:: proteins : enzyme and substrate analysis AN ABSTRACT OF THE THESIS OF Stephen S. Whitehead for the

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Creator:: Martin, Karen H.
Abstract:: The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
Resource Type:: Dissertation
Full Text:: protein did not fit the consensus sequence for N-myristylation (M-G-X-X-X- S/T/A/C/N), suggesting that it

Proteolytic maturation of vaccinia virus structural proteins

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: consensus site within the precursors, what protease(s) and/or factors are necessary for the process, and

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Creator:: Howell, Meredith L.
Abstract:: Ribonucleotide reductase is a remarkable enzyme that catalyzes the rate-limiting step in the synthesis of the 2'-deoxynucleoside triphosphates. The intent of this project was to characterize the ribonucleotide reductase encoded by the orthopoxvirus, vaccinia. The first objective was to study the structural and functional features of the viral small subunit...
Resource Type:: Dissertation
Full Text:: requirement for DNA synthesis during the S-phase of the cell cycle (Reichard, 1988). Most organisms

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Creator:: Grosenbach, Douglas W.
Abstract:: Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
Resource Type:: Dissertation
Full Text:: in that they contain at least six proteins in their outer envelope(s) that are not present on IMV

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Creator:: Lee, Peiyu
Resource Type:: Dissertation
Full Text:: Redacted for Privacy was identified which was apparently derived from the utilization of an -A-G*S

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Creator:: Spiro, Craig
Abstract:: Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
Resource Type:: Dissertation
Full Text:: DNA precursor enzymes in eukaryotic cells. They report that, during S phase, enzymes of DNA

Identification and analysis of vaccinia virus acylproteins

Creator:: Hansen, Scott G.
Abstract:: Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
Resource Type:: Dissertation
Full Text:: . Palm itylat ion I Ger anvlgeranvi Cys/SeriThr - S - - (CH)4Cft 4. Myristyl at ion CHACE-L)ICONH - G1

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

Creator:: Child, Stephanie J.
Abstract:: Vaccinia virus (VV), the prototype member of the orthopoxvirus family, is a large virus of complex morphology which contains a 191 Kbp double-stranded DNA genome whose expression is tightly regulated in a temporal fashion during viral replication. The regulation of gene expression can be exerted at various of levels, including...
Resource Type:: Dissertation

ScholarsArchive@OSU

Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Proteolytic maturation of Vaccinia virus structural proteins : enzyme and substrate analysis

Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

Proteolytic maturation of vaccinia virus structural proteins

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

Proteolytic maturation of vaccinia virus virion-associated proteins : analysis of substrate determinants

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Identification and analysis of vaccinia virus acylproteins

Evidence for the modification of vaccinia virus core proteins by ADP-ribosylation

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