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Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Creator:: Abugrain, Mostafa E.
Abstract:: Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
Resource Type:: Dissertation
Full Text:: Mahmud Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomyces

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Creator:: Mahapatra, Subham
Abstract:: More than 30 members of the diverse amphidinolide family of biologically active macrolides have been isolated over last three decades. From this family, amphidinolides C and F stand among the most complex and densely functionalized affiliates. Recently, we have accomplished the first total synthesis of amphidinolide F. The all-carbon framework...
Resource Type:: Dissertation

Biosynthesis and modification of the antibiotic enduracidin

Creator:: Goebel, Neal C.
Abstract:: The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Resource Type:: Dissertation
Full Text:: , 2012. Title: Biosynthesis and Modification of the Antibiotic Enduracidin Abstract approved: T. Mark

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation

Biosynthetic engineering of new pactamycins

Creator:: Lu, Wanli
Abstract:: Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...
Resource Type:: Dissertation
Full Text:: unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5- membered ring

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Creator:: Jackson, Michael D.
Resource Type:: Dissertation
Full Text:: nucleoside antibiotic produced by Streptomyces Iavendulae var. L-1689-23. The biosynthesis of the

Advanced studies of blasticidin S biosynthesis

Creator:: Zhang, Qibo
Resource Type:: Dissertation
Full Text:: S (BS, 1) is a peptidyl nucleoside antibiotic produced by Streptomyces griseochromogenes. The

Synthetic studies on the macrolide antibiotic rutamycin B

Creator:: Wang, Shan
Resource Type:: Dissertation
Full Text:: Synthetic studies on the macrolide antibiotic rutamycin B AN

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: nitrosative deamination with N,N-diphenylnitrosamine. Synthesis of the known precursor 220 to the antibiotic

ScholarsArchive@OSU

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Biosynthesis and Rational Design of Novel Pactamycin Analogs

Part I: Total synthesis of marine macrolide amphidinolide F and synthetic studies toward amphidinolide C; Part II: Computational study on proline sulfonamide-catalyzed aldol reaction

Biosynthesis and modification of the antibiotic enduracidin

Studies toward the total synthesis of sanglifehrin A

Biosynthetic engineering of new pactamycins

Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

Advanced studies of blasticidin S biosynthesis

Synthetic studies on the macrolide antibiotic rutamycin B

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

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