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Filtering by: Creator Eby, Sean D. Remove constraint Creator: Eby, Sean D. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

    Creator:
    Zhang, Lulu
    Abstract:
    Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Recently researchers have discovered that groups of small non-coding RNAs

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Sean M. Burrows

  • Gold Nanostars: Spectroscopic and Physical Properties

    Creator:
    Zhou, Lixia
    Abstract:
    Tethering fluorophores on metal nanoparticles for metal enhanced fluorescence (MEF) has attracted a lot of attention from scientists interested in fluorescence based approaches. MEF has many benefits in fluorescence related techniques, because the analytical signal increases and enables potentially lower detection limits or better sensitivity. Many types of nanoparticles have...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Tethering fluorophores on metal nanoparticles for metal enhanced

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Sean M. Burrows Fluorescence has

  • Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

    Creator:
    Stierwalt, Harrison D.
    Abstract:
    Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Harrison D

  • Outdoor Behavioral Healthcare Outcomes for Young Adults

    Creator:
    Roberts, Sean D.
    Abstract:
    Those experiencing significant psychosocial problems in adolescence and young adulthood are at higher risk for psychological disorder (Pottick, Bilder, Vander Stoep, Warner, & Alvarez, 2008). Compared to peers, these individuals struggle to complete school, fit with social roles, and acquire occupational skills necessary for adulthood (Pottick et al., 2008). Providing...
    Resource Type:
    Dissertation
    Full Text:
    OF THE DISSERTATION OF Sean D. Roberts for the degree of Doctor of Philosophy in Counseling

  • Regulation of Skeletal Muscle Mitophagy in Response to High-fat Feeding and Exercise Training

    Creator:
    Ehrlicher, Sarah E.
    Abstract:
    Understanding the mechanisms regulating mitochondrial respiratory function and adaptations to metabolic challenges, such as exercise and high dietary fat, is necessary to promote skeletal muscle health and attenuate metabolic disease. Autophagy is a constitutively active degradation pathway that promotes mitochondrial turnover and is suppressed by insulin and activated by exercise....
    Resource Type:
    Dissertation
    Full Text:
    E. Ehrlicher1, Harrison D. Stierwalt1, Sean A. Newsom1 and Matthew M. Robinson1 1School of

  • Regulation of skeletal muscle mitochondria in response to obesity and exercise in mice and humans

    Creator:
    Batterson, Philip M.
    Abstract:
    Skeletal muscle mitochondria are highly plastic organelles, integral to whole-body health. High-fat diet (HFD) and exercise remodel the skeletal muscle mitochondria. Whereby, altered skeletal muscle mitochondrial function is linked to decreased skeletal muscle insulin sensitivity which can be reversed by exercise. However, the mechanisms that contribute to skeletal muscle remodeling...
    Resource Type:
    Dissertation
    Full Text:
    Sean A. Newsom Skeletal muscle mitochondria are highly plastic organelles

  • The presence and characterization of measurement error in forestry

    Creator:
    Canavan, Sean Joseph
    Abstract:
    Measurement error (ME) is a component of any study involving the use of actual measurements, but is often not recognized or is ignored. The consequences of MEs on estimates of tree and stand attributes and the parameters and predictions of forest models can be varied and severe, including the presence...
    Resource Type:
    Dissertation

  • Task and support surface constraints on the coordination and control of posture in older adults

    Creator:
    Clark, Sean
    Abstract:
    Although research evidence clearly indicates support surface properties are a major factor contributing to fall risk among the elderly, investigations examining the influence of variations in surface conditions on the postural control of older adults during task performance have been limited. Thus, the primary purpose of the present studies was...
    Resource Type:
    Dissertation
    Full Text:
    control of posture in older adults AN ABSTRACT OF THE DISSERTATION OF Sean Clark for the degree of