Index Catalog // ScholarsArchive@OSU

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________________________ Robert L. Tanguay Zebrafish are capable of fully regenerating organs and tissue such as

Nanoparticle features and their relative influence on biological responses

Creator:: Denluck, Lindsay
Abstract:: Nanoparticles (NPs), defined as materials having at least one dimension (height, width, diameter) in the nanoscale, are increasingly being incorporated into a wide variety of products and are replacing traditional bulk materials in many applications. This is because they can be more efficacious, more sustainable, and can have unique characteristics...
Resource Type:: Dissertation
Full Text:: Features and their Relative Influence on Biological Responses Abstract approved: Robert L. Tanguay

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: zebrafish Abstract approved: ______________________________________________________ Robert L

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: : _________________________________________________________________ Staci L. Massey Simonich Robert L. Tanguay

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Robert L. Tanguay There are more than 87,000 chemicals in current use with little to no

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Creator:: Fisher, Joseph A.
Abstract:: Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...
Resource Type:: Dissertation
Full Text:: : E. Andrés Houseman Robert L. Tanguay Laboratories around the world are using the zebrafish model

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Creator:: Wehmas, Leah C.
Abstract:: The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Resource Type:: Dissertation
Full Text:: Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model Abstract approved: Robert L

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:: Knecht, Andrea L.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs

Fostering relevance in introductory biology courses : an empirical study of the effects of a socio-scientific issues-based course on student motivation through the lens of self-determination theory

Creator:: Hewitt, Krissi M.
Abstract:: There has been a rapid increase in technological advances in the biological sciences that has contributed to an increase in societal issues that require attention from both scientists and citizens. Consequently, there is a need for the development of biologically literate citizens who have the ability to use their knowledge...
Resource Type:: Dissertation
Full Text:: Abstract approved: ________________________________________________________________ Jana L. Bouwma

ScholarsArchive@OSU

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Nanoparticle features and their relative influence on biological responses

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Fostering relevance in introductory biology courses : an empirical study of the effects of a socio-scientific issues-based course on student motivation through the lens of self-determination theory

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search