Index Catalog // ScholarsArchive@OSU

Dissecting mechanics of chromosome segregation and cleavage furrow induction

Creator:: Chen, Wei
Abstract:: Accurate chromosome segregation and cell cleavage are critical to maintaining genomic integrity. Both events involve the spindle apparatus, but the exact mechanics is as puzzling as the contradicting models proposed in the last two centuries. In this dissertation, current prevailing models of chromosome segregation and cell cleavage are tested using...
Resource Type:: Dissertation

The aging endoplasmic reticulum

Creator:: Dixon, Brian M.
Abstract:: Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Resource Type:: Dissertation
Full Text:: M. Hagen Hallmarks of aging include the accumulation of aberrant proteins and a lower

Ecosystem Photosynthesis and Forest-Atmosphere Interactions Inferred from Carbonyl Sulfide

Creator:: Rastogi, Bharat
Abstract:: An increase in anthropogenic activities since the industrial revolution, primarily due to burning of fossil fuels and changes in land cover, has resulted in a steady increase in the global mean atmospheric CO2 concentrations. While there is unequivocal scientific evidence on global warming and its multidimensional impacts on natural and...
Resource Type:: Dissertation
Full Text:: revolution, primarily due to burning of fossil fuels and changes in land cover, has resulted in a steady

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: . Ishmael Natural products from both terrestrial and marine sources represent a significant source of

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Creator:: Hau, Andrew M.
Abstract:: Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Resource Type:: Dissertation
Full Text:: Jang and Jeffrey A. Greenwood. Syntheses and preparation of putative coibamide A and related

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:: Rhoads, Timothy W.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
Resource Type:: Dissertation
Full Text:: : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

Creator:: Allan, Sarah E.
Abstract:: Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
Resource Type:: Dissertation
Full Text:: . Abstract approved:______________________________________________________ Kim A. Anderson

The detection of superoxide and implications for amyotrophic lateral sclerosis

Creator:: Robinson, Kristine M.
Abstract:: Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
Resource Type:: Dissertation
Full Text:: provide a stable source for in vitro experimentation. Second, the products from the peroxynitrite

Experiments and Observations on How Changes in Riparian Forests Affect Light and Stream Ecosystems

Creator:: Swartz, Allison G.
Abstract:: Riparian zones are ecotones between terrestrial and aquatic ecosystems. Processes in streams are strongly influenced by riparian forest communities, age, stage and structure. Temperate forests across much of North America, including riparian areas, are recovering from historic land clearing with many stands in the stem-exclusion phase of development in which...
Resource Type:: Dissertation
Full Text:: development in which a high density of young or early-mature trees create a single uniform canopy. This

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Creator:: Barsamian, Adam L.
Abstract:: Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
Resource Type:: Dissertation
Full Text:: case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates

ScholarsArchive@OSU

Dissecting mechanics of chromosome segregation and cleavage furrow induction

The aging endoplasmic reticulum

Ecosystem Photosynthesis and Forest-Atmosphere Interactions Inferred from Carbonyl Sulfide

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

The detection of superoxide and implications for amyotrophic lateral sclerosis

Experiments and Observations on How Changes in Riparian Forests Affect Light and Stream Ecosystems

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

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