Index Catalog // ScholarsArchive@OSU

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:: Song, Zifeng
Abstract:: Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Claudia S. Maier Mass

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Creator:: Quinn, Matthew J.
Abstract:: The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
Resource Type:: Dissertation
Full Text:: Antiporters and Methyl- Accepting Chemotaxis Proteins in Vibrio cholerae Abstract approved: Claudia

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:: Wu, Jianyong
Abstract:: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Resource Type:: Dissertation
Full Text:: Peptide Adducts of Lipid Peroxidation-Derived Aldehydes Abstract approved: Dr. Claudia S

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Creator:: Chavez, Juan D.
Abstract:: Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...
Resource Type:: Dissertation
Full Text:: :___________________________ Claudia S. Maier Oxidative stress is recognized as an important underlying factor in the

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: : Claudia S. Maier Dysfunction of mitochondria has been linked to aging and the pathogenesis of many

Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Creator:: Troxel, Claudia McLaughlin
Resource Type:: Dissertation
Full Text:: of CYP1A induction on aflatoxin B₁ metabolism in zebrafish AN ABSTRACT OF THE THESIS OF Claudia

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Claudia F. Bravo for the

Characterization of interferon and retroposon-like repetitive elements in salmonid fish

Creator:: Tengelsen, Leslie A.
Abstract:: Hatchery-reared salmonid fish routinely encounter stress due to handling, barging, tagging, and overcrowding. It has been demonstrated that there exists a direct correlation between stress and transient immune suppression which can last for many days in fish. Epizootic viral infections routinely appear in hatcheries and can have a devastating effect...
Resource Type:: Dissertation
Full Text:: Interferon and Retroposon-like Repetitive Elements in Salmonid Fish Abstract approved: Jo-Ann C.1,::Z

A descriptive study of the locus of control in selected medical office assisting students and its relationship to certain characteristics an academic success as measured by grade achievement

Creator:: Bode, Elizabeth Ann
Abstract:: The central purpose of this research was to investigate the relationship of locus of control and academic success in selected medical office assisting students. The instrument for locus of control assessment was the Adult Nowicki-Strickland Internal-External Scale (ANSIES). Structured interviews were used to elicit personal responses for the purpose of...
Resource Type:: Dissertation
Full Text:: measured by grade achievement AN ABSTRACT OF THE THESIS OF Elizabeth Ann Bode for the degree of Doctor

ScholarsArchive@OSU

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Characterization of interferon and retroposon-like repetitive elements in salmonid fish

A descriptive study of the locus of control in selected medical office assisting students and its relationship to certain characteristics an academic success as measured by grade achievement

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