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Filtering by: Creator McFadden, Andrew K. Remove constraint Creator: McFadden, Andrew K. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Protein methylation at sites of blood vessel injury

    Creator:
    Weber, Darin J.
    Abstract:
    Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
    Resource Type:
    Dissertation
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    Methylation at Sites of Blood Vessel Injury. Abstract approved: Philip N. McFadden Blood vessel injury was

  • Incorporation of chromatophores into multi-cellular biosensors

    Creator:
    Preston, R. Ryan
    Abstract:
    Methodologies that detect biologically active substances have important potential applications for medical diagnostics, drug discovery, and chemical and biological anti-terrorism efforts. The wide spectrum of potential analytes that induce a physiological response dictates that novel techniques be developed to more rapidly screen and characterize agents that are more economical and...
    Resource Type:
    Dissertation
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    : Incorporation of Chromatophores into Multi-Cellular Biosensors. Abstract approved: Philip N. McFadden

  • The spatial resolution of information in a diffusive cytoplasm

    Creator:
    Sellers, Drew L.
    Abstract:
    Every cell is faced continuously with the task of transducing a vast number of external signals into appropriate intracellular responses. In mammalian cells, membrane bound receptors modulate the production of secondary messenger molecules, such as cyclic AMP (cAMP). Cell signaling through second messengers relies on the diffusion of such second...
    Resource Type:
    Dissertation
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    Information in a Diffusive Cytoplasm. Abstract approved: Philip N. McFadden Every cell is faced continuously

  • Automethylation : a response to enzyme aging

    Creator:
    Lindquist, Jonathan A.
    Abstract:
    This is the first study to explore the ability of an enzyme to recognize and repair spontaneous age-dependent damage to its own sequence. Protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase (PCM) is known to repair damage that arises from a spontaneous isomerization of aspartyl and asparaginyl residues in other proteins during aging. As...
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    Dissertation
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    approved: Philip N. McFadden This is the first study to explore the ability ofan enzyme to recognize

  • The stability of pelargonidin-based anthocyanins in natural and model systems

    Creator:
    Garzon, G. Astrid
    Abstract:
    Pelargonidin 3-glucoside (pgd 3-glu), pelargonidin 3-sophoroside (pgd 3-soph), and pelargonidin 3-sophoroside 5-glucoside acylated with cinnamic and malonic acids (acyl-pgd 3-soph 5-glu) were extracted from strawberries (Fragaria anannassa cv, Totem), nasturtium flowers (Tropaeolum majus), and radish peel (Raphanus sativus L. cv, fuego), respectively. Their stability was studied in natural and model...
    Resource Type:
    Dissertation
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    of my committee members, especially Dr. Dan Selivonchick, Dr. Phil McFadden and Dr. Fred Ramsey

  • Sublethal effects of UV-B radiation on larval amphibians

    Creator:
    Belden, Lisa K.
    Abstract:
    Ultraviolet-B radiation (UV-B) has been suggested as a factor contributing to global amphibian population declines. While ambient UV-B levels damage the eggs and embryos of some amphibian species, few studies have addressed how UV-B affects other life history stages or sublethal responses. My dissertation focuses on (1) investigations of sublethal...
    Resource Type:
    Dissertation

  • The economics of forest-dependent regions

    Creator:
    Biswas, Smita
    Abstract:
    This dissertation explores two economic phenomena involving forest-dependent areas: wage distribution and migration pattern of individuals. Are forest-dependent rural areas less desirable for workers from the standpoint of labor market returns? Are different skills (e.g. education, experience) rewarded differently in these areas? If there are interregional wage differences, would that...
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    Dissertation
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    Abstract approved: ____________________________________________________ Andrew J. Plantinga This

  • The Effects of Host and Pathogen Variation on Infection Dynamics in the Amphibian-Chytrid System

    Creator:
    Dang, Trang D.
    Abstract:
    This dissertation uses manipulative experiments to explore amphibian-Bd infection dynamics. Although there has been almost two decades research since the discovery of Bd, many questions still remain regarding what conditions mediate chytridiomycosis virulence. My research shows how certain host and pathogen factors can influence disease virulence. Identifying how host and...
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    Dissertation
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    : ______________________________________________________ Andrew R. Blaustein This dissertation uses manipulative experiments to explore

  • All hosts are not created equal : variation in amphibian responses to an emerging fungal pathogen and why it matters

    Creator:
    Gervasi, Stephanie S.
    Abstract:
    Emerging infectious diseases are increasing globally and are a threat to human, wildlife, and ecosystem health. The emerging fungal pathogen, Batrachochytrium dendrobatidis (Bd), or amphibian chytrid fungus, is associated with worldwide amphibian population declines and extinctions. Bd has been found on every continent where amphibians exist and has been documented...
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    Dissertation
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    Responses to an Emerging Fungal Pathogen and Why it Matters Abstract approved: Andrew R. Blaustein

  • Exploring the structural dynamics of human understanding : an historico-philosophical analysis of the problem of meaning in Heidegger and Bohr

    Creator:
    Tattersall, Mason
    Abstract:
    This dissertation explores the structural dynamics of human understanding and particularly the concept of meaning and its connections to concepts of ultimate ground, necessity and contingency, language, and perception. It focuses on the history of the concept of meaning in early twentieth-century European physics and philosophy, through an analysis of...
    Resource Type:
    Dissertation
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    may have seemed. Phil McFadden, with his passion for philosophical exploration, encouragement, and