Index Catalog // ScholarsArchive@OSU

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

Creator:: Buser, Jessica Z.
Abstract:: Freshwater systems cycle carbon along a spatial and temporal biogeochemical continuum, across which ecosystem processes contribute to transformations of organic matter (OM). Various ecological constraints impact rates OM transformation and production and consumption of the energetic end of respiration, methane. Microbiological processing and complete reduction of carbon substrates to methane...
Resource Type:: Dissertation
Full Text:: biogeochemist. This includes but is not limited to my committee Byron Crump, Kim Halsey, Laura Lapham, Kerry

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

Creator:: Back, Daniel C.
Abstract:: Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
Resource Type:: Dissertation
Full Text:: . Kerry McPhail and Dr. Aleksandra Sikora, I am thankful for all of the conversations we have shared and

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation

Non-viral Vectors for Ocular Gene Delivery

Creator:: Herrera-Barerra, Marco, F.
Abstract:: Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Resource Type:: Dissertation

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Creator:: Fraser, Valerie N.
Abstract:: Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
Resource Type:: Dissertation
Full Text:: , and Dr. Kerry McPhail—thank you for your personal and professional mentorship and support, as well

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Creator:: Eida, Auday
Abstract:: Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
Resource Type:: Dissertation
Full Text:: members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Creator:: Nosal, Daniel Grzegorz
Abstract:: Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
Resource Type:: Dissertation
Full Text:: from my graduate committee, Dr. Aleksandra Sikora, Dr. Benjamin Philmus, Dr. Kerry McPhail and Dr

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: inspire and motivate me throughout my future endeavors. In addition, I need to thank Prof. Kerry

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation

Secondary Metabolism in Tolypocladium : Characterization, Ecology, Evolution and Regulation

Creator:: Blount, Rheannon Rua
Abstract:: An increased understanding of secondary metabolism in fungi is important for both biological and societal reasons. The ascomycete genus, Tolypocladium, is an ideal system to explore secondary metabolism characterization, ecology, evolution and regulation. The genus produces and has the genomic potential to produce a wide array of metabolites. Paired with...
Resource Type:: Dissertation
Full Text:: patience in that lab. Kerry McPhail was a close second advisor though this process. With her support

ScholarsArchive@OSU

Biogeochemical Processing of Freshwater Carbon in the Anthropocene

Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Non-viral Vectors for Ocular Gene Delivery

Investigating Transcriptional Control of Specialized Gene Expression in Plants

Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Secondary Metabolism in Tolypocladium : Characterization, Ecology, Evolution and Regulation

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