DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
The purpose of this project was to investigate play and our cultural assumptions as to its usefulness or lack there of. The concepts of hard work versus hard play were explored in order to discover when human beings are operating at their best. In terms of innovation and productivity in...
Rockfish of the genus Sebastes are important components of Oregon reef communities. I examined patterns of age and growth in young-of-year rockfish across two nested spatial scales – local and regional – along the Oregon coast. Using otolith microstructural examination, I examined the relative importance of local versus regional factors...