Index Catalog // ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis
Full Text:: /d0md00196a. (39) Marquez Loza, A.; Elias, V.; Wong, C. P.; Ho, E.; Bermudez, M.; Magnusson, K. R. Effects of

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Creator:: Reynolds-Lallement, Nadjalisse C.
Abstract:: This study applied a virtual rendition of the Morris water maze, which is commonly used for assessing spatial memory in rodents, to an examination of age-related differences in spatial learning among 42 younger (18-30 years) and older (>60 years) male human participants. Virtual Morris water maze performance was measured by...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: Kathy Magnusson This study applied a virtual rendition of the

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

Creator:: Mollusky, Adina J.
Abstract:: This study applied a virtual version of the Morris water maze (vMWM) task to an examination of age-related differences between younger and older participants, and the impact of prior military service in older men on spatial memory and cognitive flexibility. Participants performed the Logical Memory task that included immediate and...
Resource Type:: Honors College Thesis
Full Text:: Kathy Magnusson This study applied a virtual version of the Morris water maze (vMWM) task to an

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences, College of Veterinary

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Biomedical Sciences Jennifer Johns, Committee Member, representing Clinical Pathology Kathy Magnusson

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Creator:: Vasudevan, Anusha
Abstract:: Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Resource Type:: Honors College Thesis
Full Text:: 2014, 1, 14. https://doi.org/10.3389/fnut.2014.00014. 3. Wong, C. P.; Magnusson, K. R.; Sharpton

The Effect of Zinc Status and Age on Liver Health in Mice

Creator:: Braun, Kendra N.
Abstract:: Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
Resource Type:: Honors College Thesis
Full Text:: . Mol Nutr Food Res, 56(1), 77–87. https://doi.org/10.1002/mnfr.201100511 Wong, C. P., Magnusson, K. R

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Creator:: Starman, Alia
Abstract:: Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

Creator:: Ward, Casey J.
Abstract:: Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants and elderly. Knowledge of viral and host protein interactions is important for better understanding of the viral pathogenesis and may lead to development of novel therapeutic drugs. Here, we show that RSV Matrix (M) protein interacts with cellular...
Resource Type:: Honors College Thesis
Full Text:: Manoj K. Pastey Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants

ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Age-related differences in brain activations during spatial memory formation in a virtual Morris water maze task

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

The Role of Nrf2 in Brain Cellular Senescence

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

The Effect of Zinc Status and Age on Liver Health in Mice

Generating Communication -Deficient and -Intensified Neurons to Determine Effects on Multicellular Information Networks

Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

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