Index Catalog // ScholarsArchive@OSU

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

Creator:: Ramras, Monique A.
Abstract:: Pseudocapillaria tomentosa is a nematode that parasitizes Danio rerio, causing major disease that affects the economic commodities of fish industries and destroys experimental results at research facilities. There is a critical need for a rapid and sensitive diagnostic assay to test for P. tomentosa in D. rerio populations. PCR primers...
Resource Type:: Honors College Thesis
Full Text:: .” Journal of Clinical Investigation, vol. 122, no. 7, 2 July 2012, pp. 2337–2343., doi:10.1172/jci60434

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: normal glucose homeostasis. Journal of Clinical Investigation. 2006;116(4):1102-1109. doi:10.1172

The effect of feeding spent hemp biomass on bone growth in broiler chickens

Creator:: Pearce, Carolyn
Abstract:: Spent hemp biomass (SHB) is a byproduct of the cannabinoid oil production which currently is not approved as a livestock feed ingredient. The 2018 Farm Bill defined the difference between varieties of the cannabis sativa plant as either non-hemp cannabis or hemp which has equal to or less than 0.3...
Resource Type:: Honors College Thesis
Full Text:: hematopoietic stem/progenitor cell trafficking. J. Clin. Invest. 129:2920–2931. doi:10.1172/JCI124829.

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

Creator:: VanderHoek, Eden N.
Abstract:: Human epidermal growth factor receptor 2 (HER2), a member of the receptor tyrosine kinase (RTK) family, is frequently dysregulated in a variety of cancers. Overexpression of the receptor leads to increased cell proliferation and resistance to cell death due to downstream signaling effects. Proteasomal degradation of HER2 results in the...
Resource Type:: Honors College Thesis
Full Text:: . 2015, pp. 3335–37. PubMed Central, doi:10.1172/JCI83871.

Self-Advocacy for Female Patients with Chronic Pain

Creator:: Smith, McGwire
Abstract:: A significant proportion of the population of the United States suffers from chronic pain, a category of disease that is not yet well understood by healthcare professionals. A majority of this group is made up of women; individuals who often have to convince healthcare professionals that their symptoms are real...
Resource Type:: Honors College Thesis
Full Text:: :10.1172/jci45178. Wright, Danyeal M., et al. “Activation of Membrane Estrogen Receptors Attenuates NOP

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

Role of MEK Mutations in Trametinib Resistant Acute Myeloid Leukemia Cells

Creator:: Beer, Sofia R.
Abstract:: Acute myeloid leukemia (AML) is a blood malignancy characterized by a differentiation and proliferation defect of myeloid progenitors leading to accumulation of myeloid blasts. It is one of the most common leukemias in adults. Trametinib (Mekinist) is a small molecule inhibitor that targets MEK1 (MAP2K1) and MEK2 (MAPK2K2). It has...
Resource Type:: Honors College Thesis
Full Text:: investigation, 108(6), 851– 859. doi:10.1172/JCI12807 7. Leukemia. (2019). Retrieved June 21, 2019, from

Stress and Learning in Larval Zebrafish (Danio rerio)

Creator:: Moussaoui, Bushra
Abstract:: In this study, we characterize the behavioral response of larval zebrafish (Danio rerio) to the noxious chemical allyl isothiocyanate (AITC), an agonist of the nociceptive TRPA1 ion channel, and utilize AITC as an aversive stimulus in an associative learning paradigm. We find that larvae exposed to AITC in both a...
Resource Type:: Honors College Thesis
Full Text:: Journal of Clinical Investigation, 120(11), 3760–3772. https://doi.org/10.1172/JCI42843 Ellis, T

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

Creator:: Nagra, Alamjit K.
Abstract:: Immature T cells, known as thymocytes, undergo development through successive stages in the thymus and the periphery to become functional mature T cells. These stages are regulated by sequence specific transcription factors (SSTFs). Two such SSTFs, BCL11B and TCF-1, are both known master regulators of thymopoiesis, which is also known...
Resource Type:: Honors College Thesis

ScholarsArchive@OSU

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

The effect of feeding spent hemp biomass on bone growth in broiler chickens

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

Self-Advocacy for Female Patients with Chronic Pain

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Role of MEK Mutations in Trametinib Resistant Acute Myeloid Leukemia Cells

Stress and Learning in Larval Zebrafish (Danio rerio)

Characterizing the Interaction between BCL11B and TCF-1 transcription factors in the control of the BCL-xL gene

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