Index Catalog // ScholarsArchive@OSU

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Creator:: McKinney, Madison J.
Abstract:: Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Resource Type:: Honors College Thesis
Full Text:: Nucleic Acid Based Therapeutics for Treatment of Cystic

Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Creator:: Kapoor, Hannah A.
Abstract:: Mycobacterium abscessus (MAB) is an opportunistic pathogen responsible for infections in immunocompromised or immunosuppressed patients. Even with long-term treatment with multiple antibiotics, MAB pulmonary infections have high rates of treatment failure. Within the host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical...
Resource Type:: Honors College Thesis
Full Text:: some of the aspects of phage therapy by Hannah Kapoor A THESIS submitted to Oregon State

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Creator:: Snow, Erika
Abstract:: Respiratory illnesses caused by both viral and bacterial infection are serious issues for global healthcare providers. With the emergence of new, drug-resistant forms of these diseases, innovative drugs and treatment therapies are needed. M tuberculosis is an infection that affects a large portion of the world’s population each year. Aerosol...
Resource Type:: Honors College Thesis
Full Text:: . Oligonucleotide synthesis is a well-established approach to synthesizing short fragments of nucleic acids with a

Integration of Amino Acid Sequence and Alphafold2 Structural Predictions for Chlamydia trachomatis Polymorphic Membrane Proteins

Creator:: DeBrine, Abigail
Abstract:: Chlamydia trachomatis is an obligate intracellular bacterium that causes diseases of the eye and urogenital tract in humans. It is the cause of the sexual transmitted infection (STI) chlamydia, the most prevalent STI worldwide, and the ocular disease trachoma, the leading cause of infectious blindness. To date there is no...
Resource Type:: Honors College Thesis
Full Text:: States as Determined by the Aptima Trichomonas Vaginalis Nucleic Acid Amplification Assay. J Clin

Tuning tRNA and EF-Tu for the Efficient Site-specific Incorporation of Noncanonical Amino Acids into Proteins

Creator:: Gottfried-Lee, Ilana L.
Abstract:: Genetic code expansion (GCE) is a technology that allows us to incorporate noncanonical amino acids (ncAAs) site-specifically into recombinant proteins using engineered translational machinery. Typically, an orthogonal aaRS/tRNA pair is engineered by directed evolution to recognize the ncAA and incorporate it at a reassigned codon while not interacting with the...
Resource Type:: Honors College Thesis
Full Text:: -specific Incorporation of Noncanonical Amino Acids into Proteins by Ilana Gottfried-Lee

Development and Characterization of Multiple Nanopore Systems for Molecular Sensing

Creator:: Schmeckpeper, Tyler T.
Abstract:: Artificial lipid bilayer technologies are effective models for studying cell membrane properties. Droplet bilayers rely on microfluidics and provide advantages over other bilayer methods due to their compatibility with automated development systems that increase yield while minimizing cost. This paper describes the implementation of bilayer technologies using membrane protein channels...
Resource Type:: Honors College Thesis
Full Text:: integrated into ALB nanopores on a chip with a cocaine-binding aptamer. Aptamers are nucleic acid

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:: Hobbs, Helen T.
Abstract:: As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...
Resource Type:: Honors College Thesis
Full Text:: oxidative damage, oxidants can react with biomolecules, including lipids, nucleic acids, and proteins, and

Liquid-liquid Phase Separation of the Nucleocapsid of SARS-CoV-2

Creator:: Hughes, Kaitlyn
Abstract:: The nucleocapsid of SARS-CoV-2 is critical for viral genome packaging through binding to viral genomic RNA. Liquid-liquid phase separation, or LLPS, is the formation of microscopic, rapidly reversible, liquid-like immiscible droplets. There is increasing scientific evidence that LLPS underlies the formation of membraneless compartments within cells and that this process...
Resource Type:: Honors College Thesis
Full Text:: recruitment of proteins, nucleic acids, and other compounds to this confined space (Wang, 2021). As the name

Investigating Local Energy Compensation of Adjacent RNA Secondary Structures in the bpRNA-1m Database

Creator:: Cornwell-Arquitt, Robert L.
Abstract:: Non-coding ribonucleic acid (ncRNA) is of interest for its diverse roles in cell and viral biology. RNA molecules vary greatly in terms of size, structure, and function. In recent years, the modification of existing RNA structures has been used for biochemical methods of enormous impact including CRISPR and RNAi methods....
Resource Type:: Honors College Thesis
Full Text:: Honors Baccalaureate of Science in Biochemistry and Molecular Biology (Honors Scholar

Regulation of the Metabolic Reprogramming of Schwannoma Cells by Nitrated Hsp90

Creator:: Bastian, Lydia P.
Abstract:: This work is concerned with determining whether nicotine has a role in promoting oxidative damage in human tissue, particularly in lung tissue. This follows from recent reports of a novel lung disease found in some E-cigarette users, characterized by oxidative damage and elevated levels of neutrophils (termed “vaping disease”). It...
Resource Type:: Honors College Thesis
Full Text:: Molecular Biology (Honors Scholar) Presented June 2, 2020 Commencement June 2020

ScholarsArchive@OSU

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Integration of Amino Acid Sequence and Alphafold2 Structural Predictions for Chlamydia trachomatis Polymorphic Membrane Proteins

Tuning tRNA and EF-Tu for the Efficient Site-specific Incorporation of Noncanonical Amino Acids into Proteins

Development and Characterization of Multiple Nanopore Systems for Molecular Sensing

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Liquid-liquid Phase Separation of the Nucleocapsid of SARS-CoV-2

Investigating Local Energy Compensation of Adjacent RNA Secondary Structures in the bpRNA-1m Database

Regulation of the Metabolic Reprogramming of Schwannoma Cells by Nitrated Hsp90

Limit your search

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search