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Investigating the Role of the MutLα Endonuclease

Creator:

Mankaney, Gautam Naresh

Abstract:

Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...

Resource Type:

Honors College Thesis

Full Text:

porcine trypsin in 137 mM NaCl, 5 mM KCl, 6 mM dextrose, 7 mM sodium bicarbonate, 0.7 mM EDTA, and 5 μM