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The role of CYP2E1 and CYP4A in the development of non-alcoholic steatohepatitis

Creator:

Hawkins, Jenna M.

Abstract:

Non-alcoholic Steatohepatitis (NASH) is an emerging form of liver disease associated with obesity, type II diabetes and dyslipidemia. As the prevalence of these metabolic conditions increases, so too has the occurrence of NASH in all sectors of the population. The pathology of this disease is similar to its alcoholic form,...

Resource Type:

Honors College Thesis

Full Text:

scheme: NADPH + H+ + R + O2  NADP+ + H2O + ROH (R= substrate, ROH= product) In mammals the