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Genomic identification of candidate inclusion membrane proteins in Chlamydial species and microscopic analysis

Creator:

Blake, Nathanael A.

Abstract:

The Chlamydiaceae are a family of obligate intracellular bacteria with a unique biphasic developmental cycle. The replicating, metabolically active, intracellular phase bacteria (RBs) grow within a cellular vacuole know as the inclusion. Since the proteins the Chlamydiaceae secrete into this membrane are the means of host/parasite interaction, they have long...

Resource Type:

Honors College Thesis

Full Text:

proteins, protein localization Corresponding e-mail: aure.entuluva@gmail.com
The role of chlamydial inclusion membrane proteins in host-pathogen interaction and the development of novel methods for studying chlamydial biology

Creator:

Alzhanov, Damir T.

Abstract:

The majority of our modern understanding of bacterial pathogenesis is based on the strategy that involves screening bacterial genomes for the presence of the genes encoding pathogenic factors, and analysis of these genes via forward and reverse genetics. Chlamydiae represent a unique group of pathogenic bacteria in which it is...

Resource Type:

Dissertation

Full Text:

bacterial OmpA protein, exposed on the surface of EB (143), and heparan sulfate containing