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Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:

Zhang, Yong

Abstract:

Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...

Resource Type:

Dissertation

Full Text:

. Paul Murtaugh, Dr. Claudia Maier and Dr. Lan Xue for their invaluable support and feedback during
Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Creator:

Fei, Xiaobo

Abstract:

Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...

Resource Type:

Masters Thesis

Full Text:

. Maier, and Dr. Rockey for their guidance and assistance throughout my graduate studies. I would like