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Filtering by: Creator Demessie, E. Sahle File Format pdf License All rights reserved

Targeted Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues

Creator:

Park, Youngrong, Korzun, Tetiana, Moses, Abraham S., Singh, Prem, Levasseur, Peter R., Demessie, Ananiya A., Sharma, Kongbrailatpam Shitaljit, Morgan, Terry, Raitmayr, Constanze J., Avila, Uriel, Sabei, Fahad Y., Taratula, Olena R., Marks, Daniel L., and Taratula, Oleh

Abstract:

Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...

Resource Type:

Article

Full Text:

, Peter R. Levasseur, Ananiya A. Demessie, Kongbrailatpam Shitaljit Sharma, Terry Morgan, Constanze J
Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Creator:

Rivera, Brianna N.

Abstract:

Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...

Resource Type:

Dissertation