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Effect of Protease Inhibitors on Steady-State Pharmacokinetics of Oral Norethindrone Contraception in HIV-Infected Women

Creator:

Atrio, Jessica, Stanczyk, Frank Z., Neely, Michael, Cherala, Ganesh, Kovacs, Andrea, and Mishell, Daniel R., Jr.

Abstract:

OBJECTIVE: Pharmacokinetic interactions exist between combined oral contraceptives and protease inhibitors (PI). However, such information is lacking for progestin-only oral contraception. We sought to define the steady-state pharmacokinetic interaction between norethindrone (NET) and PI in HIV-infected women. METHODS AND DESIGN: We conducted an open-label, prospective, nonrandomized trial to characterize the...

Resource Type:

Article

Full Text:

. Journal of Acquired Immune Deficiency Syndromes, 65(1), 72-77. doi:10.1097/QAI.0b013e3182a9b3f1 10.1097