OBJECTIVE: Pharmacokinetic interactions exist between combined
oral contraceptives and protease inhibitors (PI). However, such
information is lacking for progestin-only oral contraception. We
sought to define the steady-state pharmacokinetic interaction between
norethindrone (NET) and PI in HIV-infected women.
METHODS AND DESIGN: We conducted an open-label, prospective,
nonrandomized trial to characterize the...
Hydraulic conductance of leaves (K[subscript leaf]) typically decreases with increasing water stress and recent studies have proposed different mechanisms responsible for decreasing K[subscript leaf]. We measured K[subscript leaf] concurrently with ultrasonic acoustic emissions (UAEs) in dehydrating leaves of several species to determine whether declining K[subscript leaf] was associated with xylem...
Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...