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Filtering by: Creator Sobsey, Mark D. Has journal sim PLoS ONE Non-Academic Affiliation Linus Pauling Institute

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:

Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.

Abstract:

The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...

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vertebrate central nervous system. Citation: Miller GW, Ulatowski L, Labut EM, Lebold KM, Manor D, et al
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:

Lytle, Kelli A. and Jump, Donald B.

Abstract:

Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...

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Reversible? Lytle, K. A., & Jump, D. B. (2016). Is Western Diet-Induced Nonalcoholic Steatohepatitis in