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Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos

Creator:

Lebold, Katie M., Kirkwood, Jays S., Taylor, Alan W., Choi, Jaewoo, Barton, Carrie L., Miller, Galen W., La Du, Jane, Jump, Donald B., Stevens, Jan Frederik, Tanguay, Robert L., and Traber, Maret G.

Abstract:

To test the hypothesis that embryogenesis depends upon α-tocopherol (E) to protect embryo polyunsaturated fatty acids (PUFAs) from lipid peroxidation, new methodologies were applied to measure α-tocopherol and fatty acids in extracts from saponified zebrafish embryos. A solid phase extraction method was developed to separate the analyte classes, using a...

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liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and
Lipidomics and H₂¹⁸O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

Creator:

McDougall, Melissa Q., Choi, Jaewoo, Stevens, Jan F., Truong, Lisa, Tanguay, Robert L., and Traber, Maret G.

Abstract:

We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without...

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Article

ScholarsArchive@OSU

Novel liquid chromatography–mass spectrometry method shows that vitamin E deficiency depletes arachidonic and docosahexaenoic acids in zebrafish (Danio rerio) embryos

Lipidomics and H₂¹⁸O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

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